YN340235 AT9283

AT9283 is a potent JAK2/3 inhibitor with IC50 of 1.2 nM/1.1 nM in cell-free assays also potent to Aurora A/B, Abl(T315I). Phase 2.

YN350233 Rhoifolin 17306-46-6

Rhoifolin is a flavone glycoside isolated fromCitrus gr and is(L.) Osbeck leaves. Rhoifolin is beneficial for diabetic complications through enhanced adiponectin secretion, tyrosine phosphorylation ofinsulin receptor-β and glucose tra...

YN330596 Ginsenoside Rg5 186763-78-0

Ginsenoside Rg5 is the main component of Red ginseng. Ginsenoside blocks binding ofIGF-1to its receptor with an IC50 of ~90nM. Ginsenoside Rg5 also inhibits the mRNA expression ofCOX-2via suppression of the DNA binding ...

YN330515 Isochlorogenic acid A 2450-53-5

Isochlorogenic acid A (3,5-Dicaffeoylquinic acid) is a natural phenolic acid with antioxidant and anti-inflammatory activities .

YN370213 Heparan Sulfate 9050-30-0

Heparan sulfate, a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix.

YN340044 HKI-357 848133-17-5

HKI-357 is an irreversible dual inhibitor ofEGFR and ERBB2with IC50s of 34nM and 33nM, respectively. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation.

YN340146 BDTX-189 2414572-47-5

BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations with Kd of 0.2 nM, 0.76 nM, 13 nM and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively....

YN340046 AV-412 free base 451492-95-8

AV-412 free base (MP-412 free base) is an EGFRinhibitor with IC50s of 0.75, 0.5, 0.79, 2.3, 19nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M and ErbB2, respectively.

YN340008 Tyrphostin AG 528 133550-49-9

Tyrphostin AG-528 is a potent inhibitor of epidermal growth factor receptors (EGFR) and ErbB2/HER2 with IC50 of 4.9 μM and 2.1 μM, respectively. Tyrphostin AG-528 exhibits anticancer activity.

YN340150 WHI-P154 211555-04-3

WHI-P154 is a potent JAK3 inhibitor with IC50 of 1.8 μM, no activity against JAK1 or JAK2, also inhibits EGFR, Src, Abl, VEGFR and MAPK, prevents Stat3, but not Stat5 phosphorylation.

YN340211 PD158780 171179-06-9

PD158780 is a potentEGFRfamily inhibitor with IC50s of 8 pM, 49, 52, 52nM for EGFR, ErbB2, ErbB3, and ErbB4, respectively.

YN340004 AEE788 497839-62-0

AEE788 (NVP-AEE788) is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKCα and CDK1. P...

YN340039 Falnidamol 196612-93-8

Falnidamol (BIBX 1382) is an orally active, selectiveEGFR tyrosine kinaseinhibitor with an IC50 of 3nM. Falnidamol displays > 1000-fold lower potency against ErbB2 (IC50=3.4μM) and a range of other related tyrosine kina...

YN340047 Canertinib 267243-28-7

Canertinib (CI-1033) is a pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, no activity to PDGFR, FGFR, InsR, PKC, or CDK1/2/4. Phase 3.

YN340048 Canertinib dihydrochloride 289499-45-2

Canertinib (CI-1033, PD-183805, compound 18) dihydrochloride is a potent and irreversible inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. Canertinib dihydrochloride inhibits cellular EGFR an...