YN310285 Inauhzin 309271-94-1

Inauhzin is a cell-permeable SIRT1 inhibitor with an IC50 of 0.7-2 μM and reactivates p53 by inhibiting SIRT1 deacetylation activity.

YN310347 Agrimol B 55576-66-4

Agrimol B is a polyphenol derived fromAgrimonia pilosa Ledeb, suppresses adipogenesis via inducingSIRT1translocation and expression, and reducingPPARγexpression.

YN310017 AGK2 304896-28-4

AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.

YN310266 Selisistat 49843-98-3

Selisistat (EX 527) is a potent and selective SIRT1 inhibitor with IC50 of 38 nM in a cell-free assay, exhibits >200-fold selectivity against SIRT2 and SIRT3. Phase 2.

YN310339 Suramin sodium salt 129-46-4

Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitiveprotein-tyrosine phosphatases (PTPases)inhibitor. Suramin sodium salt is a potent inhibitor ofsirtuins: SirT1 (IC50=297nM), SirT2 (IC50=1.15μM),...