YN330546 Polygalasaponin F 882664-74-6

Polygalasaponin F, an oleanane-type triterpenoid saponin extracted fromPolygala japonica, decreases the release of the inflammatory cytokine tumor necrosis factor a (TNFa). Polygalasaponin F reduces neuroinflammatory cytokine secret...

YN330580 Isofraxidin 486-21-5

Isofraxidin possesses significant analgesic and anti-inflammatory activities that may be mediated through the regulation of pro-inflammatory cytokines, TNF-α and the phosphorylation of p38 and ERK1/ Isofraxidin has definite anti-ba...

YN330197 IAXO-102 1115270-63-7

IAXO-102 is aTLR4antagonist which negatively regulates TLR4 signalling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experiment...

YN330102 Resatorvid 243984-11-4

Resatorvid (TAK-242) is a selectiveToll-like receptor 4 (TLR4)inhibitor. Resatorvid inhibitsNO, TNF-R and IL-6production with IC50s of 1.8nM, 1.9nM and 1.3nM, respectively. Resatorvid downregulates expression of TL...

YN330148 Sparstolonin B 1259330-61-4

Sparstolonin B acts as a selectiveTLR2 and TLR4antagonist and selectively blocks TLR2- and TLR4-mediated inflammatory signaling. Sparstolonin B has anti-HIV and anticancer activities.