YN410053 Desfluoro-ezetimibe 302781-98-2

Desfluoro-ezetimibe is a desfluoro impurity of Ezetimibe. Ezetimibe is a potent, metabolically stablecholesterol absorptioninhibitor. Ezetimibe is aNiemann-Pick C1-like1 (NPC1L1)inhibitor, and is a potentNrf2activator.

YN410069 CDDO-Im 443104-02-7

CDDO-Im (CDDO-Imidazolide, RTA-403, TP-235) is an activator of nuclear factor erythroid 2–related factor 2 (Nrf2) and peroxisome proliferator-activated receptor (PPAR). CDDO-Im binds to PPARα and...

YN410001 ML385 846557-71-9

ML385 is a novel and specific NRF2 inhibitor with an IC50 of 1.9 μM. It inhibits the downstream target gene expression of NRF2.

YN410029 CDDO-EA 932730-51-3

CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator.

YN410019 CDDO-dhTFEA 1191265-33-4

CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activatesNrf2 and inhibits the pro-inflammatory transcription factorNF-κB. CDDO-dhTFEA restores hypertension (MAP), increases N...

YN410089 Curcumin D6 1246833-26-0

Curcumin D6 (Diferuloylmethane D6) is a deuterium labeled Curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with diverse pharmacologic effects including anti-inflammatory, antioxidant, antiprolife...

YN410152 TAT-14 1362661-34-4

TAT-14 is a 14-mer peptide that acts asNrf2activator with an anti-inflammatory effect. TAT-14 has no effect on Nrf2 mRNA expression, but increases Nrf2 protein level due to targeting the Nrf2 binding site on Keap1.

YN410080 NK-252 1414963-82-8

NK-252 is a potentialNrf2activator, which exhibits a greatNrf2-activating potential.

YN410016 ML334 1432500-66-7

ML334 is a potent, cell permeable activator ofNRF2by inhibition ofKeap1-NRF2protein-protein interaction. ML334 binds to Keap1 Kelch domain with aKdof 1μM. ML334 stimulatesNRF2expression and nuclear translocation and ...

YN410002 Nrf2-IN-1 1610022-76-8

Nrf2-IN-1 is an inhibitor ofnuclear factor-erythroid 2-related factor 2 (Nrf2). Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).

YN410004 KI696 isomer 1799974-69-8

KI696 isomer is the less active isomer of KI696 (HY-101140). KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction.

YN410003 KI696 1799974-70-1

KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction. KI696 is a potent and selective inhibitor of theKEAP1/NRF2interaction.

YN410033 Keap1-Nrf2-IN-1 2232112-72-8

Keap1-Nrf2-IN-1 (compound35) is aKelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interactioninhibitor, and with an IC50 of 43nM for Keap1 protein. Keap1-Nrf2-IN...

YN410049 CBR-470-2 2416095-00-4

CBR-470-2, a glycine-substituted analog, and can activateNRF2signaling. CBR-470-2 can be used for modulation glycolysis.

YN410050 CBR-470-1 2416095-06-0

CBR-470-1 is an inhibitor of theglycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalentNrf2activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP+-induced cytotoxicity through acti...