YN440149 JH-VIII-157-02 1639422-97-1

JH-VIII-157-02 is a structural analogue of alectinib, acts as anALKinhibitor, and shows an IC50 of 2nM for echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) G1202R in cells.

YN440218 TGFβRI-IN-2 1976038-41-1

TGFβRI-IN-2 (compound 18) is a potent, selective and orally active(Activin-Like Kinase 5) ALK 5inhibitor withpIC50 and pEC50values of 7.6 and 6.63, respectively. TGFβRI-IN-2 can produce observed cardiac toxicit...

YN440087 Ensartinib hydrochloride 2137030-98-7

Ensartinib (X-396) is a potent new-generation ALK inhibitor with high activity against a broad range of known crizotinib-resistant ALK mutations and CNS metastases. It potently inhibits both wild-type ALK and ALK va...

YN440282 TL13-22 2229036-65-9

TL13-22 is a negative control for TL13-12 (HY-122582) and a potentALKinhibitor with an IC50 of 0.54nM. TL13-22 does not degradeALKin cells.

YN440283 TL13-110 2229037-09-4

TL13-110 is a negative control for TL13-112 (HY-123919) and a potent ALK inhibitor with an IC50 of 0.34nM. TL13-110 does not degradeALKin cells.

YN440094 A 83-01

A 83-01 is a potent inhibitor of TGF-β type I receptorALK5 kinase, type I nodal receptorALK4 and type I nodal receptorALK7, with IC50s of 12nM, 45nM and 7.5nM against the transcription induced byALK5,ALK4 and ...