ATR inhibitor 2
Cat. No. :YN420176
CAS No. :1613191-99-3
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Product Name: | ATR inhibitor 2 |
CAS NO.: | 1613191-99-3 |
Chemical Name: | |
Synonyms: | ATR inhibitor 2 |
Molecular Weight: | 541.55 |
Molecular Formula: | C₂₅H₂₉F₂N₉O₃ |
SMILES: | O=C(C1=C2N=CC(F)=CN2N=C1N)NC3=C(N4CCC(C(N5CCN(C6COC6)CC5)=O)CC4)C(F)=CN=C3 |
Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
Transportation: | Room temperature in continental US; may vary elsewhere. |
Description: | VX-803 (M4344) is an ATP-competitive, orally active, and selective inhibitor of ataxia telangiectasia and Rad3 related (ATR) kinase with Ki of < 150 pM. VX-803 (M4344) potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (P-Chk1) phosphorylation with IC50 of 8 nM. VX-803 (M4344) exhibits potential antineoplastic activity. |
IC50&Target: | |
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References: |
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