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ATR inhibitor 2

Cat. No. :YN420176

  • CAS No. :1613191-99-3

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    • Product Name:ATR inhibitor 2
      CAS NO.:1613191-99-3
      Chemical Name:
      Synonyms:ATR inhibitor 2
      Molecular Weight:541.55
      Molecular Formula:C₂₅H₂₉F₂N₉O₃
      SMILES:O=C(C1=C2N=CC(F)=CN2N=C1N)NC3=C(N4CCC(C(N5CCN(C6COC6)CC5)=O)CC4)C(F)=CN=C3
      Storage:Please store the product under the recommended conditions in the Certificate of Analysis.
      Transportation:Room temperature in continental US; may vary elsewhere.
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    • Description:VX-803 (M4344) is an ATP-competitive, orally active, and selective inhibitor of ataxia telangiectasia and Rad3 related (ATR) kinase with Ki of < 150 pM. VX-803 (M4344) potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (P-Chk1) phosphorylation with IC50 of 8 nM. VX-803 (M4344) exhibits potential antineoplastic activity.
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