Acalabrutinib
Cat. No. :YN440368
CAS No. :1420477-60-6
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order@ubiochem.com| Product Name: | Acalabrutinib |
| CAS NO.: | 1420477-60-6 |
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| Molecular Weight: | 465.51 |
| Molecular Formula: | C₂₆H₂₃N₇O₂ |
| SMILES: | O=C(NC1=NC=CC=C1)C2=CC=C(C3=C4C(N)=NC=CN4C([C@H]5N(C(C#CC)=O)CCC5)=N3)C=C2 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Acalabrutinib(ACP-196) is a selective second-generation Bruton's tyrosine kinase (BTK) inhibitor with an IC50 of 3 nM, which prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. ACP-196 has improved target specificity over ibrutinib with 323-, 94-, 19- and 9-fold selectivity over the other TEC kinase family members (ITK, TXK, BMX, and TEC, respectively) and no activity against EGFR. |
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