TAS-116
Cat. No. :YN372343
CAS No. :1260533-36-5
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order@ubiochem.com| Product Name: | TAS-116 |
| CAS NO.: | 1260533-36-5 |
| Chemical Name: | |
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| Molecular Weight: | 454.53 |
| Molecular Formula: | C₂₅H₂₆N₈O |
| SMILES: | O=C(N)C1=CC=C(N2N=C(C(C)C)C3=C(N4C=C(C5=CN(C)N=C5)N=C4)C=CN=C32)C(CC)=C1 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | TAS-116 is a novel, small-molecule HSP90 inhibitor which inhibits geldanamycin-FITC binding to HSP90 proteins with Ki values of 34.7 nmol/L, 21.3 nmol/L, >50,000 nmol/L, and >50,000 nmol/L for HSP90α, HSP90β, GRP94, and TRAP1, respectively. Furthermore, TAS-116 does not inhibit other ATPases such as HSP70 (IC50 >200 μmol/L). |
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