ML346
Cat. No. :YN372500
CAS No. :100872-83-1
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order@ubiochem.com| Product Name: | ML346 |
| CAS NO.: | 100872-83-1 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 272.26 |
| Molecular Formula: | C₁₄H₁₂N₂O₄ |
| SMILES: | O=C1NC(/C(C(N1)=O)=C/C=C/C2=CC=C(OC)C=C2)=O |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | ML346 is an activator ofHsp70 expression and HSF-1 activity, with an EC50 of 4.6μM for Hsp70. ML346 restores protein folding in conformational disease models, without significant cytotoxicity or lack of specificity. ML346 induces specific increases in genes and protein effectors of the heat shock response (HSR), including chaperones such as Hsp70, Hsp40, and Hsp27. |
| IC50&Target: | |
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