SNX-2112
Cat. No. :YN370235
CAS No. :908112-43-6
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order@ubiochem.com| Product Name: | SNX-2112 |
| CAS NO.: | 908112-43-6 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 464.48 |
| Molecular Formula: | C₂₃H₂₇F₃N₄O₃ |
| SMILES: | O=C1CC(C)(C)CC2=C1C(C(F)(F)F)=NN2C3=CC=C(C(N[C@H]4CC[C@@H](CC4)O)=C3)C(N)=O |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | SNX-2112 (PF 04928473) is an orally activeHsp90inhibitor, with aKdof 16nM forHsp90 and IC50s of 30nM, 30nM for Hsp90 α and Hsp90 β, also induces Her-2 degradation, and inhibits Grp94 and Trap-1, with IC50s of 10 nM, 4.275μM and 0.862μM, respectively. SNX-2112 (PF 04928473) binds Hsp90 isoforms Hsp90α, Hsp90β and Hsp90b1/Grp94 with Kds of 4nM, 6nM and 484nM, respectively. |
| IC50&Target: | |
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| References: |
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