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Cot inhibitor-2

Cat. No. :YN350207

  • CAS No. :915363-56-3

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    • Products Infomation
    • Biological Activity
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    • Product Name:Cot inhibitor-2
      CAS NO.:915363-56-3
      Chemical Name:
      Synonyms:
      Molecular Weight:539.43
      Molecular Formula:C₂₆H₂₅Cl₂FN₈
      SMILES:N#CC1=C(C2=CC(NCC3=CN(N=N3)C4CCN(CC4)CC)=CC(Cl)=C2N=C1)NC5=CC=C(F)C(Cl)=C5
      Storage:Please store the product under the recommended conditions in the Certificate of Analysis.
      Transportation:Room temperature in continental US; may vary elsewhere.
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    • Description:Cot inhibitor-2 is a potent, selective and orally activecot (Tpl2/MAP3K8)inhibitor with an IC50 of 1.6nM. Cot inhibitor-2 inhibts TNF-α production in LPS-stimulated human whole blood with an IC50 of 0.3μM.
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