DLK-IN-1
Cat. No. :YN350086
CAS No. :1620574-24-4
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order@ubiochem.com| Product Name: | DLK-IN-1 |
| CAS NO.: | 1620574-24-4 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 423.43 |
| Molecular Formula: | C₂₀H₂₄F₃N₅O₂ |
| SMILES: | CC(N1C([C@@H]2[C@]3([H])[C@@]2([H])CN(C4COC4)C3)=CC(C5=CN=C(N)C(OC(F)(F)F)=C5)=N1)C |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | DLK-IN-1 is a selective, orally active inhibitor of dual leucine zipper kinase(DLK, MAP3K12), with a Ki of 3nM. DLK-IN-1 retains excellent CNS penetration and is well tolerated following multiple days of dosing at concentrations that exceed those required for DLK inhibition in the brain. DLK-IN-1 has activity in a model of Alzheimer’s Disease. |
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