SEA0400
Cat. No. :YN360545
CAS No. :223104-29-8
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order@ubiochem.com| Product Name: | SEA0400 |
| CAS NO.: | 223104-29-8 |
| Chemical Name: | |
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| Molecular Weight: | 371.38 |
| Molecular Formula: | C₂₁H₁₉F₂NO₃ |
| SMILES: | NC1=CC(OCC)=CC=C1OC2=CC=C(OCC3=CC(F)=CC=C3F)C=C2 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | SEA0400 is a selective and potent inhibitor of the Na+-Ca2+ exchanger (NCX) that inhibits Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50 of 33 nM, 5.0 nM and 8.3 nM, respectively. SEA0400 prevents sodium nitroprusside (SNP) from increasing ERK and p38 MAPK phosphorylation and production of reactive oxygen species (ROS) in an extracellular Ca(2+)-dependent manner. |
| IC50&Target: | |
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