TH-237A
Cat. No. :YN480445
CAS No. :935467-97-3
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5mg
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order@ubiochem.com| Product Name: | TH-237A |
| CAS NO.: | 935467-97-3 |
| Chemical Name: | |
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| Molecular Weight: | 333.33 |
| Molecular Formula: | C₁₈H₁₇F₂NO₃ |
| SMILES: | OCC12N([C@H](C3=CC=C(F)C=C3)OC2)[C@@H](C4=CC=C(F)C=C4)OC1 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | TH-237A(meso-GS 164) is a novel neuroprotective agent exhibiting favorable permeation across the blood brain barrier. IC50 value: 5nM (EC50, concentration that leads to a 50% increase in neuronal survival in the presence of the Aβ peptides Primary neurons were isolated from embryonic Sprague-Dawley rats, grown in culture (Michaelis et al., 1994) and exposed to either Aβ25-35 or Aβ1-42 in the presence or absence of TH-237A at concentrations ranging from 0.5 to 60nM. The neurons were treated with TH-237A for 2 hours prior to exposure to the Aβ peptides. Changes in neuronal survival following treatment with TH 237A were evaluated using the Live/Dead assay. The EC50 for TH-237A was 5nM, demonstrating that it had excellent neuroprotective properties. |
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