YN290283 PJ34 hydrochloride 344458-15-7

PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.

YN290284 PJ34 344458-19-1

PJ34 is a potent specific inhibitor ofPARPl/2with IC50 of 110nM and 86nM, respectively.

YN290065 Rucaparib phosphate 459868-92-9

Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains. Phase 3.

YN310258 INO-1001 501364-82-5

INO-1001 is a potent and selectivepoly (ADP-ribose) polymerase (PARP)inhibitor. INO-1001 is a potent enhancer of radiation sensitivity and enhances radiation-induced cell killing by interfering with DNA repair mechanisms...

YN310253 JW 55 664993-53-7

JW55 is a potent and selective inhibitor of the canonical Wnt pathway that functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2).

YN310299 WIKI4 838818-26-1

WIKI4 is a novel Tankyrase inhibitor with IC50 of 15 nM for TNKS2, and leads to inhibition of Wnt/beta-catenin signaling.

YN310076 A-966492 934162-61-5

A-966492 is a novel and potent inhibitor ofPARP1 and PARP2with Kiof 1nM and 1.5nM, respectively.

YN310078 Niraparib (R-enantiomer) 1038915-58-0

Niraparib R-enantiomer (MK-4827 R-enantiomer) is an excellentPARP1inhibitor with IC50 of 2.4nM.

YN310077 Niraparib hydrochloride 1038915-64-8

Niraparib hydrochloride (MK-4827 hydrochloride) is a highly potent and orally bioavailablePARP1 and PARP2inhibitor with IC50s of 3.8 and 2.1nM, respectively. Niraparib hydrochloride leads to inhibition of repair of DNA...

YN310256 UPF 1069 1048371-03-4

UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM. It is ~27-fold selective against PARP1.

YN310097 BYK204165 1104546-89-5

BYK204165 is a potent and selective inhibitor of the poly(ADP-ribose) polymerase (PARP). BYK204165 inhibits cell-free recombinant human PARP-1 (hPARP-1) with pIC50 of 7.35 and pKi of 7.05 and murine PARP-2...

YN290194 E7449 1140964-99-3

E7449 is an orally bioavailable, brain penetrable, small molecule dual inhibitor of PARP1/2 and also inhibits PARP5a/5b, otherwise known as tankyrase1 and 2 (TNKS1/2), important regulators of canonical Wnt/β-catenin signaling...

YN310223 AZD-2461 1174043-16-3

AZD2461 is a novel PARP inhibitor with low affinity for Pgp than Olaparib. Phase 1.

YN310096 EB-47 dihydrochloride 1190332-25-2

EB-47 dihydrochloride, a potent and selectivePARP-1/ARTD-1inhibitor with an IC50 value of 45nM, shows modest potency against ARTD5 with an IC50 value of 410nM. EB-47 mimics the substrate NAD+ and extends from the...

YN310289 (8R,9S)-Talazoparib 1207456-00-5

(8R,9S)-Talazoparib ((8R,9S)-BMN-673) is an enantiomer of Talazoparib (HY-16106). (8R,9S)-Talazoparib is anPARP1inhibitor, with an IC50 of 144nM.

YN290382 Talazoparib 1207456-01-6

Talazoparib (BMN-673) is a highly potent, orally availablePARP1/2inhibitor.Talazoparib inhibits PARP1 and PARP2 enzyme activity with Kis of 1.2 and 0.87nM, respectively. Talazoparib has antitumor activity.

YN310309 NMS-P118 1262417-51-5

NMS-P118 is a potent, orally available, and highly selective PARP-1 inhibitor endowed with excellent ADME and pharmacokinetic profiles, showing 150-fold selectivity for PARP-1 over PARP-2 (Kd 0.009 μM vs 1.39 μM, re...

YN290084 Talazoparib tosylate 1373431-65-2

Talazoparib tosylate (BMN 673ts) is a novel, potent and orally availablePARP1/2inhibitor with an IC50 of 0.57nM for PARP1.

YN290200 G007-LK 1380672-07-0

G007-LK is a potent and selective tankyrase inhibitor with IC50 of 46 nM and 25 nM for TNKS1/2, respectively.

YN310255 NVP-TNKS656 1419949-20-4

NVP-TNKS656 is a highly potent, selective, and orally active tankyrase inhibitor with IC50 of 6 nM for TNKS2, > 300-fold selectivity against PARP1 and PARP2.