GSK-25
Cat. No. :YN350144
CAS No. :874119-56-9
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5mg
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25mg
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order@ubiochem.com| Product Name: | GSK-25 |
| CAS NO.: | 874119-56-9 |
| Chemical Name: | |
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| Molecular Weight: | 513.33 |
| Molecular Formula: | C₂₄H₁₆Cl₂F₂N₆O |
| SMILES: | ClC1=CC(C2=NC(C3=C(F)C=C(Cl)C=C3)C(C(NC4=C(F)C=C(NN=C5)C5=C4)=O)=C(C)N2)=CC=N1 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | GSK-25 is a potent, selective and orally bioavailableROCK1inhibitor (IC50=7nM). GSK-25 maintains good selectivity against a panel of 31 kinases (>100 fold), as well as RSK1 and p70S6K (RSK1: IC50=398nM, p70S6K: IC50=1μM). GSK-25 inhibits P450 profile (IC50s of 2.5, 5.2, 2.5 µM for CYP2C9, CYP2D6, CYP3A4, respectively). |
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