Gefitinib-based PROTAC 3
Cat. No. :YN340098
CAS No. :2230821-27-7
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order@ubiochem.com| Product Name: | Gefitinib-based PROTAC 3 |
| CAS NO.: | 2230821-27-7 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 934.51 |
| Molecular Formula: | C₄₇H₅₇ClFN₇O₈S |
| SMILES: | O=C([C@H]1N(C([C@@H](NC(CCOCCOCCCCCOC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2OC)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL lig and via a linker, inducesEGFRdegradation withDC50s of 11.7nM and 22.3nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively. |
| IC50&Target: | |
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| Clinical Trial: | |
| Solvent & Solubility: | |
| References: |
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