TAS0728
Cat. No. :YN340073
CAS No. :2088323-16-2
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order@ubiochem.com| Product Name: | TAS0728 |
| CAS NO.: | 2088323-16-2 |
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| Molecular Weight: | 504.58 |
| Molecular Formula: | C₂₆H₃₂N₈O₃ |
| SMILES: | NC1=C2C(N([C@H]3CN(C(C=C)=O)CCC3)N=C2C(NC4=CC=C(CC(N(C)C)=O)C(C)=C4C)=O)=NC=N1 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | TAS0728 is a potent, selective, orally active, irreversible and covalent-bindingHER2inhibitor, binds to HER2 at C805, inhibits its kinase activity, with an IC50 of 13nM. TAS0728 shows IC50s of 4.9, 8.5, 31, 65, 33, 25, 86 and 36nM for BMX, HER4, BLK, EGFR, JAK3, SLK, LOK and human HER2, respectively. TAS0728 also inhibits the phosphorylation of HER2, HER3, and downstream effectors, shows no obvious effect on EGFR. Antitumor activity. |
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