BMS-599626 Hydrochloride
Cat. No. :YN340094
CAS No. :873837-23-1
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order@ubiochem.com| Product Name: | BMS-599626 Hydrochloride |
| CAS NO.: | 873837-23-1 |
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| Molecular Weight: | 567.01 |
| Molecular Formula: | C₂₇H₂₈ClFN₈O₃ |
| SMILES: | O=C(OC[C@H]1NCCOC1)NC2=CN(C3=C2C)N=CN=C3NC4=CC5=C(C=C4)N(CC6=CC(F)=CC=C6)N=C5.Cl |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | BMS-599626 Hydrochloride (AC480 Hydrochloride) is a selective and orally bioavailableHER1 and HER2inhibitor, with IC50s of 20 and 30nM, respectively. BMS-599626 Hydrochloride displays ~8-fold less potent to HER4 (IC50=190nM), >100-fold to VEGFR2, c-Kit, Lck, MEK. BMS-599626 Hydrochloride inhibits tumor cell proliferation, and has potential to increase tumor response to radiotherapy. |
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