Mutated EGFR-IN-2
Cat. No. :YN340116
CAS No. :2050906-97-1
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order@ubiochem.com| Product Name: | Mutated EGFR-IN-2 |
| CAS NO.: | 2050906-97-1 |
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| Molecular Weight: | 562.64 |
| Molecular Formula: | C₂₉H₃₅FN₈O₃ |
| SMILES: | C=CC(NC1=CC(NC2=NC=CC(N3C4=CC=C(F)C=C4N(C(C)C)C3=O)=N2)=C(OC)C=C1N(CCN(C)C)C)=O |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Mutated EGFR-IN-2 (compound 91) is a mutant-selectiveEGFRinhibitor extracted from patent WO2017036263A1, which potently inhibits single-mutant EGFR (T790M) and double-mutant EGFR (including L858R/T790M (IC50=＜1nM) and ex19del/T790M), and can suppress activity of single gain-of-function mutant EGFR (including L858R and ex19del) as well. Mutated EGFR-IN-2 shows anti-tumor antivity. |
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