EGFR-IN-11
Cat. No. :YN340122
CAS No. :2463200-44-2
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order@ubiochem.com| Product Name: | EGFR-IN-11 |
| CAS NO.: | 2463200-44-2 |
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| Molecular Weight: | 573.71 |
| Molecular Formula: | C₂₉H₃₅N₉O₂S |
| SMILES: | CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC4=C(C=N3)N=C(NC5=CC=CC=C5)N4[C@H]6CN(CC6)S(C7CC7)(=O)=O |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | EGFR-IN-11 is a fourth-generationEGFR-tyrosine kinase inhibitor (EGFR-TKI) with an IC50 of 18nM for triple mutantEGFRL858R/T790M/C797S. EGFR-IN-11 significantly suppresses the EGFR phosphorylation, induce the apoptosis, and arrest cell cycle at G0/G1. |
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