YN310372 5,​7,​4'-​Trimethoxyflavon... 5631-70-9

5,7,4'-Trimethoxyflavone is isolated fromKaempferia parviflora(KP) that is a famous medicinal plant from Thail and . 5,7,4'-Trimethoxyflavone inducesapoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin...

YN310353 5,7-Dihydroxychromone 31721-94-5

5,7-Dihydroxychromone, the extract ofCudrania tricuspidata, activatesNrf2/AREsignal and exerts neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced oxidative stress and apoptosis. 5,7-Dihydroxychromone inhibits ...

YN330585 Anemarsaponin B 139051-27-7

Anemarsaponin B is a steroidal saponin isolated from the rhizomes ofA. asphodeloides(Liliaceae). Anemarsaponin B decreases the protein and mRNA levels ofiNOS and COX-2. Anemarsaponin B reduces the expressions and produc...

YN350231 Carnosol 5957-80-2

One of the phenolic antioxidants present in extracts of rosemary; inhibits the formation of tumors derived using irritants such as TPA and DMBA

YN330512 Ginsenoside Rb3 68406-26-8

Ginsenoside Rb3, extracted from the plant Panax ginseng, plays important roles in cardiovascular diseases, including myocardial ischemia-reperfusion (I/R) injury. Ginsenoside Rb3 (0.1-10 μM) is tested for inhibition of tumor necros...

YN330572 Prim-O-glucosylcimifugin 80681-45-4

Prim-O-glucosylcimifugin exerts anti-inflammatory effects through the inhibition ofiNOS and COX-2expression by through regulating JAK2/STAT3 signaling.

YN340279 Quercetagetin 90-18-6

Quercetagetin (6-Hydroxyquercetin) is the major flavonoid isolated fromCitrus unshiu(C. unshiu) peel. Quercetagetin is a moderately potent and selective, cell-permeablepim-1kinase inhibitor (IC50, 0.34μM). Anti-inflammatory and...

YN330595 Ginsenoside C-K 39262-14-1

Ginsenoside C-K, a bacterial metabolite of G-Rb1, exhibits anti-inflammatory effects by reducingiNOS and COX-2. Ginsenoside C-K exhibits an inhibition against the activity ofCYP2C9 and CYP2A6in human liver microsomes w...

YN350185 Ro 5126766 946128-88-7

RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM,19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.

YN373130 Wedelolactone 524-12-9

Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.

YN310345 Dehydrocorydaline 30045-16-0

Dehydrocorydaline exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSCLC cells. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimerization of MyoD and E proteins...

YN310259 Staurosporine 62996-74-1

Staurosporine (CGP 41251) is a potent PKC inhibitor for PKCα, PKCγ and PKCη with IC50 of 2 nM, 5 nM and 4 nM, less potent to PKCδ (20 nM), PKCε (73 nM) and little active to PKCζ (1086 nM)...

YN320112 Asenapine 65576-45-6

Asenapine is an antagonist ofserotonin receptors(5-HT2A, 5-HT2B, 5-HT2C, 5-HT6, 5-HT7),adrenoceptors(α1, α2A, α2B, α2C),dopamine receptors(D2, D3, D4) and histamine receptors(H1, H2), withpKis of 8.4-10.5, 8.9-9....

YN321624 Terfenadine 50679-08-8

Terfenadine is an antihistamine, generally completely metabolizes to the active form fexofenadine in the liver by the enzyme cytochrome P450 CYP3A4 isoform.

YN320273 AH 6809 33458-93-4

AH 6809 is an antagonist ofEP and DP receptor, with a Ki of 1217, 1150, 1597, and 1415nM for the clonedhuman EP1,EP2,EP3-III, and DP receptorrespectively, and with a Ki of 350nM formouse EP2receptor .