YN340142 CK2/ERK8-IN-1

CK2/ERK8-IN-1 is a dualcasein kinase 2 (CK2)(Kiof 0.25 µM) and ERK8(MAPK15, ERK7) inhibitor with IC50s of 0.50μM. CK2/ERK8-IN-1 also binds toPIM1,HIPK2(homeodomain-interacting protein kinase 2), and...

YN340125 EMI48 34564-13-1

EMI48, the derivative of EMI1, displays greater potency toward mutantEGFRthan EMI1. EMI48 inhibitsEGFRtriple mutants.

YN310343 Daphnetin 486-35-1

Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor, inhibits EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM, respectively, also known to exhibit anti-inflammatory and anti-oxidant activi...

YN340142 CK2/ERK8-IN-1 1085822-09-8

CK2/ERK8-IN-1 is a dualcasein kinase 2 (CK2)(Kiof 0.25 µM) and ERK8(MAPK15, ERK7) inhibitor with IC50s of 0.50μM. CK2/ERK8-IN-1 also binds toPIM1,HIPK2(homeodomain-interacting protein kinase 2), and...

YN310087 Bisindolylmaleimide X hydroc... 145317-11-9

Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selectiveprotein kinase C (PKC)inhibitor. Bisindolylmaleimide X hydrochloride is a potentcyclin-dependent kinase 2 (CDK2)antagonist with an IC50 of...

YN310090 TCS 21311 1260181-14-3

TCS 21311 (NIBR3049) is a potent, highly selectiveJAK3inhibitor with an IC50 of 8nM, it displays >100-fold selectivity over JAK1, JAK2 and TYK2. TCS 21311 (NIBR3049) inhibitsPKCα,PKCθ, and GSK3βwi...

YN350183 Longdaysin 1353867-91-0

Longdaysin is a Casein Kinase inhibitor with IC50 values of 8.8 μM, 5.6 μM, 52 μM and 29 μM for CKIδ, CKIα, ERK2 and CDK7.

YN340147 XL019 945755-56-6

XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, exhibiting >50-fold selectivity over JAK1, JAK3 and TYK2. Phase 1.

YN310181 A-3 hydrochloride 78957-85-4

A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of variouskinases. It against PKA (Ki=4.3 µM), casein kinase II (Ki=5.1 µM) and myosin light chain kinase (MLCK) (Ki=...

YN310033 HA-100 84468-24-6

HA-100 is an inhibitor of cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinasewith IC50s of 4, 8, 12 and 240μM, respectively.

YN320342 Methiothepin mesylate 74611-28-2

Methiothepin mesylate is a potent and non-selective5-HT2receptorantagonist, with pKds of 7.10 (5-HT1A), 7.28 (5HT1B), 7.56 (5HT1C), 6.99 (5HT1D), 7.0 (5-HT5A), 7.8 (5-HT5B), 8.74 (5-HT6), and 8.99 (5-HT7), and...

YN340270 Cucurbitacin I 2222-07-3

Cucurbitacin I is a natural selective inhibitor of Jak2/STAT3, with potent anti-cancer activity.

YN251433 Verbascoside 61276-17-3

Verbascoside, a phenylpropanoid glycoside from lemon verbena, has several biological properties such as anti-inflammatory, antimicrobial, antitumor, and antioxidant.

YN310308 Phorbol 12-myristate 13-aceta... 16561-29-8

Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a dualSphK and protein kinase C (PKC)activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells.

YN310151 Chelerythrine chloride 3895-92-9

Chelerythrine is a potent, selective antagonist of PKC with IC50 of 0.66 mM.