YN340235 AT9283

AT9283 is a potent JAK2/3 inhibitor with IC50 of 1.2 nM/1.1 nM in cell-free assays also potent to Aurora A/B, Abl(T315I). Phase 2.

YN330596 Ginsenoside Rg5 186763-78-0

Ginsenoside Rg5 is the main component of Red ginseng. Ginsenoside blocks binding ofIGF-1to its receptor with an IC50 of ~90nM. Ginsenoside Rg5 also inhibits the mRNA expression ofCOX-2via suppression of the DNA binding ...

YN340150 WHI-P154 211555-04-3

WHI-P154 is a potent JAK3 inhibitor with IC50 of 1.8 μM, no activity against JAK1 or JAK2, also inhibits EGFR, Src, Abl, VEGFR and MAPK, prevents Stat3, but not Stat5 phosphorylation.

YN321728 Harmine hydrochloride 343-27-1

Harmine, a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value ...

YN321729 Harmine 442-51-3

Harmine is an alkaloid of the β-carboline family that regulates PPARγ expression through inhibition of the Wnt signaling pathway. It also selectively binds to MAO-A and reversibly inhibits monoamine oxidase A (MAO-A) but n...

YN340235 AT9283 896466-04-9

AT9283 is a potent JAK2/3 inhibitor with IC50 of 1.2 nM/1.1 nM in cell-free assays also potent to Aurora A/B, Abl(T315I). Phase 2.

YN330135 RO2959 monohydrochloride 2309172-44-7

RO2959 monohydrochloride is a potent and selectiveCRAC channelinhibitor with an IC50 of 402nM. RO2959 monohydrochloride is a potent blocker ofstore operated calcium entry (SOCE)mediated byOrai1/Stim1 channelswith an IC5...

YN310090 TCS 21311 1260181-14-3

TCS 21311 (NIBR3049) is a potent, highly selectiveJAK3inhibitor with an IC50 of 8nM, it displays >100-fold selectivity over JAK1, JAK2 and TYK2. TCS 21311 (NIBR3049) inhibitsPKCα,PKCθ, and GSK3βwi...

YN330188 Nitroaspirin 175033-36-0

Nitroaspirin (NCX 4016) is a nitric oxide (NO) donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin (NCX 4016) has antithrombotic and anti-platelet properties and...

YN330625 [10]-Shogaol 36752-54-2

[10]-Shogaol is an antioxidant fromZingiber officinalefor human skin cell growth and a migration enhancer. [10]-Shogaol inhibits COX-2 with an IC50 of 7.5μM and has antiproliferation activity .

YN330626 [8]-Shogaol 36700-45-5

[8]-Shogaol, one of the pungent phenolic compounds in ginger, exhibits anti-platelet activity (IC50=5μM) and inhibits COX-2 (IC50=17.5μM). [8]-Shogaol induces apoptosis in human leukemia cells.

YN330531 Psoralidin 18642-23-4

Psoralidin, a naturally occurring coumestan isolated from the fractions of organic solvents such as ethylacetate, hexane, or n-butanol of the seed extract of Psoralea corylifolia L., has a variety of biological activities such as antican...

YN330542 (-)-Catechin gallate 130405-40-2

(-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity ofCOX-1 and COX-2enzymes.

YN330541 (+)-Catechin hydrate 225937-10-0

Catechins are a plant derived polyphenolic anti-oxidants with phytotoxic properties. (+)-Catechin hydrate is a frequent component of traditional herbal remedies, such as Uncaria rhynchophylla.

YN330286 Paradol 27113-22-0

Paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants. Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds tocyclooxygenase (COX)-2active site.