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Rhoifolin is a flavone glycoside isolated fromCitrus gr and is(L.) Osbeck leaves. Rhoifolin is beneficial for diabetic complications through enhanced adiponectin secretion, tyrosine phosphorylation ofinsulin receptor-β and glucose tra...
YN340120 Gandotinib 1229236-86-5
Gandotinib (LY2784544) is a potent JAK2 inhibitor with IC50 of 3 nM, effective in JAK2V617F, 8- and 20-fold selective versus JAK1 and JAK3. Phase 2.
YN340018 (E)-AG 99 122520-85-8
AG99 is a potent and selective inhibitor of EGFR.
YN340077 PD-089828 179343-17-0
PD-089828 is an ATP competitive inhibitor ofFGFR-1,PDGFR-β and EGFR(IC50s=0.15, 1.76, and 5.47 µM, respectively) and a noncompetitive inhibitor ofc-Srctyrosine kinase (IC50=0.18 µM). PD-089828 also inhibits...
AG-494, a member of the tyrphostin family of tyrosine kinase inhibitors, is a potent inhibitor of EGF receptor autophosphorylation (IC50=1.2 μM) and EGF-dependent cell growth (IC50=6 μM).
HKI-357 is an irreversible dual inhibitor ofEGFR and ERBB2with IC50s of 34nM and 33nM, respectively. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation.
EMI48, the derivative of EMI1, displays greater potency toward mutantEGFRthan EMI1. EMI48 inhibitsEGFRtriple mutants.
ZD-4190 is a submicromolar inhibitor of VEGF RTK activity in vitro with IC50 values of 29 ± 4 nM and 708 ± 63 nM for KDR and Flt-1, respectively.
YN340247 Mutated EGFR-IN-1 1421372-66-8
Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutatedEGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant. More information can be fo...
YN340155 Mutant EGFR inhibitor 1421373-62-7
Mutant EGFR inhibitor is a potent and selective mutantEGFRinhibitor extracted from patent WO 2013014448 A1; inhibits EGFRL858R, EGFRExon 19 deletion and EGFRT790M.
YN340146 BDTX-189 2414572-47-5
BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations with Kd of 0.2 nM, 0.76 nM, 13 nM and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively....
YN340041 CL-387785 194423-06-8
CL-387785 (EKI-785) is an irreversible, and selective EGFR inhibitor with IC50 of 370 pM.
YN340046 AV-412 free base 451492-95-8
AV-412 free base (MP-412 free base) is an EGFRinhibitor with IC50s of 0.75, 0.5, 0.79, 2.3, 19nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M and ErbB2, respectively.
WHI-P180 is a multi-kinase inhibitor with IC50 values of 4.5 and 66 nM for the human proto-oncogene RET and kinase insert domain receptor (KDR) , respectively.
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