YN340240 Gefitinib

Gefitinib (ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.

YN340018 (E)-AG 99 122520-85-8

AG99 is a potent and selective inhibitor of EGFR.

YN340077 PD-089828 179343-17-0

PD-089828 is an ATP competitive inhibitor ofFGFR-1,PDGFR-β and EGFR(IC50s=0.15, 1.76, and 5.47 µM, respectively) and a noncompetitive inhibitor ofc-Srctyrosine kinase (IC50=0.18 µM). PD-089828 also inhibits...

YN340021 AG-494 133550-35-3

AG-494, a member of the tyrphostin family of tyrosine kinase inhibitors, is a potent inhibitor of EGF receptor autophosphorylation (IC50=1.2 μM) and EGF-dependent cell growth (IC50=6 μM).

YN340044 HKI-357 848133-17-5

HKI-357 is an irreversible dual inhibitor ofEGFR and ERBB2with IC50s of 34nM and 33nM, respectively. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation.

YN340293 ZD-4190 413599-62-9

ZD-4190 is a submicromolar inhibitor of VEGF RTK activity in vitro with IC50 values of 29 ± 4 nM and 708 ± 63 nM for KDR and Flt-1, respectively.

YN340146 BDTX-189 2414572-47-5

BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations with Kd of 0.2 nM, 0.76 nM, 13 nM and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively....

YN340041 CL-387785 194423-06-8

CL-387785 (EKI-785) is an irreversible, and selective EGFR inhibitor with IC50 of 370 pM.

YN340046 AV-412 free base 451492-95-8

AV-412 free base (MP-412 free base) is an EGFRinhibitor with IC50s of 0.75, 0.5, 0.79, 2.3, 19nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M and ErbB2, respectively.

YN340183 WHI-P180 211555-08-7

WHI-P180 is a multi-kinase inhibitor with IC50 values of 4.5 and 66 nM for the human proto-oncogene RET and kinase insert domain receptor (KDR) , respectively.

YN340024 RG14620 136831-49-7

RG14620, an EGFR inhibitor of the tyrphostin family, directly inhibits the transport function of ABCG2 .

YN340008 Tyrphostin AG 528 133550-49-9

Tyrphostin AG-528 is a potent inhibitor of epidermal growth factor receptors (EGFR) and ErbB2/HER2 with IC50 of 4.9 μM and 2.1 μM, respectively. Tyrphostin AG-528 exhibits anticancer activity.

YN340045 AV-412 451493-31-5

AV-412 (MP412) is anEGFRinhibitor with IC50s of 0.75, 0.5, 0.79, 2.3, 19nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M and ErbB2, respectively.

YN340150 WHI-P154 211555-04-3

WHI-P154 is a potent JAK3 inhibitor with IC50 of 1.8 μM, no activity against JAK1 or JAK2, also inhibits EGFR, Src, Abl, VEGFR and MAPK, prevents Stat3, but not Stat5 phosphorylation.

YN340095 PD153035 Hydrochloride 183322-45-4

PD153035 Hydrochloride (SU-5271 Hydrochloride) is a potentEGFRinhibitor withKi and IC50 of 6 and 25 pM, respectively.