YN340022 NSC 228155

NSC228155 is an activator of EGFR. It binds to the sEGFR dimerization domain II and modulates EGFR tyrosine phosphorylation.

YN340044 HKI-357 848133-17-5

HKI-357 is an irreversible dual inhibitor ofEGFR and ERBB2with IC50s of 34nM and 33nM, respectively. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation.

YN340046 AV-412 free base 451492-95-8

AV-412 free base (MP-412 free base) is an EGFRinhibitor with IC50s of 0.75, 0.5, 0.79, 2.3, 19nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M and ErbB2, respectively.

YN340008 Tyrphostin AG 528 133550-49-9

Tyrphostin AG-528 is a potent inhibitor of epidermal growth factor receptors (EGFR) and ErbB2/HER2 with IC50 of 4.9 μM and 2.1 μM, respectively. Tyrphostin AG-528 exhibits anticancer activity.

YN340211 PD158780 171179-06-9

PD158780 is a potentEGFRfamily inhibitor with IC50s of 8 pM, 49, 52, 52nM for EGFR, ErbB2, ErbB3, and ErbB4, respectively.

YN340004 AEE788 497839-62-0

AEE788 (NVP-AEE788) is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKCα and CDK1. P...

YN340039 Falnidamol 196612-93-8

Falnidamol (BIBX 1382) is an orally active, selectiveEGFR tyrosine kinaseinhibitor with an IC50 of 3nM. Falnidamol displays > 1000-fold lower potency against ErbB2 (IC50=3.4μM) and a range of other related tyrosine kina...

YN340047 Canertinib 267243-28-7

Canertinib (CI-1033) is a pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, no activity to PDGFR, FGFR, InsR, PKC, or CDK1/2/4. Phase 3.

YN340048 Canertinib dihydrochloride 289499-45-2

Canertinib (CI-1033, PD-183805, compound 18) dihydrochloride is a potent and irreversible inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. Canertinib dihydrochloride inhibits cellular EGFR an...

YN340016 TX1-85-1 1603845-32-4

TX1-85-1 is an irreversible Her3 (ErbB3)inhibitor with an IC50 of 23nM. TX1-85-1 is also the first selective Her3 lig and , which forms a covalent bond with Cys721 located in the ATP-binding site of Her3. TX1-85-1 induces ...

YN340022 NSC 228155 113104-25-9

NSC228155 is an activator of EGFR. It binds to the sEGFR dimerization domain II and modulates EGFR tyrosine phosphorylation.

YN350229 Corynoxeine 630-94-4

Corynoxeine, which could be isolated from Uncaria rhynchophylla, is a useful and prospective compound in the prevention and treatment for vascular diseases. It is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC ...

YN350250 Methylnissolin 73340-41-7

Methylnissolin (Astrapterocarpan), isolated fromAstragalus membranaceus, inhibitsplatelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC50 of 10μM. Methylnissolin inhibits PDGF-BB-induced phosphory...

YN350173 Ravoxertinib 1453848-26-4

Ravoxertinib (GDC-0994) is an orally bioavailableERKkinase inhibitor with an IC50 of 6.1nM and 3.1nM forERK1 and ERK2, respectively.

YN320787 AZ12672857 945396-55-4

AZ12672857 is an orally active inhibitor ofEphB4(IC50=1.3nM) and Src kinases. AZ12672857 shows good inhibition of proliferation of c-Src transfected 3T3 cells (IC50=2nM) as well as autophosphorylation of EphB4 in transfect...