YN340192 Butein

Butein, a plant polyphenol isolated from Rhus verniciflua, is able to inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, also inhibits EGFR.

YN340192 Butein 487-52-5

Butein, a plant polyphenol isolated from Rhus verniciflua, is able to inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, also inhibits EGFR.

YN310285 Inauhzin 309271-94-1

Inauhzin is a cell-permeable SIRT1 inhibitor with an IC50 of 0.7-2 μM and reactivates p53 by inhibiting SIRT1 deacetylation activity.

YN310005 ME0328 1445251-22-8

ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.

YN321224 Roluperidone 359625-79-9

Roluperidone (CYR-101) is a novel cyclic amide derivative that has high equipotent affinities for5-HT2A and sigma-2receptors (Kiof 7.53nM and 8.19nM for 5-HT2A and sigma-2, respectively).

YN310347 Agrimol B 55576-66-4

Agrimol B is a polyphenol derived fromAgrimonia pilosa Ledeb, suppresses adipogenesis via inducingSIRT1translocation and expression, and reducingPPARγexpression.

YN310017 AGK2 304896-28-4

AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.

YN330610 Pterosin B 34175-96-7

Pterosin B, a indanone found in bracken fern (Pteridium aquilinum), is an inhibitor ofsalt-inducible kinase 3 (Sik3)signaling. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3.

YN310266 Selisistat 49843-98-3

Selisistat (EX 527) is a potent and selective SIRT1 inhibitor with IC50 of 38 nM in a cell-free assay, exhibits >200-fold selectivity against SIRT2 and SIRT3. Phase 2.

YN310141 UBCS039 358721-70-7

UBCS039 is the first synthetic, specificSirtuin 6 (SIRT6)activator, inducing autophagy in human tumor cells, with an EC50 of 38μM.

YN310339 Suramin sodium salt 129-46-4

Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitiveprotein-tyrosine phosphatases (PTPases)inhibitor. Suramin sodium salt is a potent inhibitor ofsirtuins: SirT1 (IC50=297nM), SirT2 (IC50=1.15μM),...

YN321345 Perphenazine 58-39-9

Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.