AMG-548
Cat. No. :YN350057
CAS No. :864249-60-5
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order@ubiochem.com| Product Name: | AMG-548 |
| CAS NO.: | 864249-60-5 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 461.56 |
| Molecular Formula: | C₂₉H₂₇N₅O |
| SMILES: | O=C1N(C)C(NC[C@@H](N)CC2=CC=CC=C2)=NC(C3=CC=NC=C3)=C1C4=CC=C5C=CC=CC5=C4 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | AMG-548, an orally active and selectivep38αinhibitor (Ki=0.5nM), shows slightly selective overp38β(Ki=36nM) and >1000 fold selective against p38γ and p38δ. AMG 548 is also extremely potent in the inhibition of whole blood LPS stimulatedTNFα(IC50=3nM). AMG-548 inhibits Wnt signaling by directly inhibitingCasein kinase 1isoforms δ and ε. |
| IC50&Target: | |
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| References: |
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