Crizotinib hydrochloride
Cat. No. :YN440408
CAS No. :1415560-69-8
86-020-82000279
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order@ubiochem.com| Product Name: | Crizotinib hydrochloride |
| CAS NO.: | 1415560-69-8 |
| Chemical Name: | |
| Synonyms: | Xalkori, PF-02341066 hydrochloride |
| Molecular Weight: | 486.80 |
| Molecular Formula: | C₂₁H₂₃Cl₃FN₅O |
| SMILES: | ClC1=C(F)C=CC(Cl)=C1[C@H](OC2=CC(C3=CN(N=C3)C4CCNCC4)=CN=C2N)C.[H]Cl |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Crizotinib (PF-02341066) hydrochloride (Xalkori) inhibits tyrosine phosphorylation of c-Met and nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) with IC50 of of 11 nM and 24 nM in cell-based assays, respectively. Crizotinib hydrochloride is also a potent ROS1 inhibitor with Ki less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines. |
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