Ceritinib dihydrochloride
Cat. No. :YN440336
CAS No. :1380575-43-8
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order@ubiochem.com| Product Name: | Ceritinib dihydrochloride |
| CAS NO.: | 1380575-43-8 |
| Chemical Name: | |
| Synonyms: | Zykadia, LDK378 dihydrochloride |
| Molecular Weight: | 631.06 |
| Molecular Formula: | C₂₈H₃₈Cl₃N₅O₃S |
| SMILES: | CC(C)OC1=CC(C2CCNCC2)=C(C)C=C1NC3=NC=C(Cl)C(NC4=CC=CC=C4S(=O)(C(C)C)=O)=N3.[H]Cl.[H]Cl |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Ceritinib (Zykadia, LDK378) dihydrochloride is a selective, orally bioavailable and ATP-competitive inhibitor of ALK with IC50 of 0.2 nM. Ceritinib dihydrochloride also inhibits InsR, IGF-1R and STK22D with IC50 of 7 nM, 8 nM and 23 nM, respectively. Ceritinib exhibits antitomor activity. |
| IC50&Target: | |
| In Vitro: | |
| In Vivo: | |
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| Solvent & Solubility: | |
| References: |
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