YN320763 Detomidine carboxylic acid 115664-39-6

Detomidine carboxylic acid is the major urinary metabolite of Detomidine. Detomidine is a syntheticα2-adrenergicagonist and an animal analgesic sedative. Detomidine also has cardiac and respiratory effects and an antidiuretic act...

YN321476 Levobetaxolol hydrochloride 116209-55-3

Levobetaxolol exhibits a higher affinity at cloned human β1 and β2 receptors with Ki value of 0.76 nM and 32.6 nM, respectively.

YN321426 Nebivolol 118457-14-0

Nebivolol is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and also for left ventricular failure.

YN320248 Amibegron hydrochloride 121524-09-2

Amibegron hydrochloride is a selectiveβ3-adrenoceptoragonist, with an EC50 of 3.5nM forβ-adrenoceptorin rat colon; Amibegron hydrochloride has anxiolytic and antidepressant activity.

YN320176 Deriglidole 122830-14-2

Deriglidole is a peripheraladrenoceptorantagonist with a high affinity for α2-adrenoceptors.

YN320128 BRL 37344 sodium 127299-93-8

BRL 37344 sodium (BRL 37344A) is a specificβ3-adrenergic receptoragonist. BRL 37344 sodium treatment significantly lowers the body weight of obese mice.

YN321054 Arbutamine 128470-16-6

Arbutamine is a short-acting, potent and nonselectiveβ-adrenoceptoragonist that increases heart rate, cardiac contractility, and systolic blood pressure. Arbutamine is a catecholamine for a pharmacological cardiac stress agen.

YN321203 Vatinoxan hydrochloride 130466-38-5

Vatinoxan hydrochloride (MK-467 hydrochloride;L-659066 hydrochloride) is a peripheralα2 adrenergic receptorantagonist.

YN320996 YS-49 132836-42-1

YS-49 is aPI3K/Akt(a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibitsangiotensin II (Ang II)-stimulated proliferation of VSMCs via induct...

YN320504 CL 316243 138908-40-4

CL316243 is a highly potent selectiveβ3-adrenoceptoragonist with aEC50of 3nM, but is an extremely poor to β1/2- receptors.CL316243 is a effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis ...

YN321327 Dronedarone 141626-36-0

Dronedarone is a derivative of amiodarone which is classified as a Class III antiarrhythmic agent. It shows rate-dependent inhibition of the rapid Na+ current, inhibits α and β-adrenergic receptors like Class II agents, exhibits...

YN321929 G-Protein antagonist peptide 143675-79-0

G-Protein antagonist peptide is the substance P-related peptide that inhibits binding of G proteins to their receptors. G-Protein antagonist peptide competitively and reversibly inhibitsM2 muscarinic receptoractivation of Gi or G...

YN320058 Landiolol hydrochloride 144481-98-1

Landiolol hydrochloride is a drug which acts as a highly cardioselective, ultra short-acting beta blocker.

YN321105 Dexmedetomidine hydrochloride 145108-58-3

Dexmedetomidine HCl is a highly selective and potent alpha-2 adrenoceptor agonist, which reduces anesthetic requirements for patients by providing significant sedation.

YN322028 MG 1 148274-76-4

MG 1 is an α1adrenergic receptorantagonist.

YN321399 Ivabradine hydrochloride 148849-67-6

Ivabradine HCl, a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent.

YN320178 QF0301B 149247-12-1

QF0301B is anα1 adrenergic receptorantagonist and a low α2 adrenoceptor, 5-HT2A, and histamine H1 receptor blocker.

YN321427 Nebivolol hydrochloride 152520-56-4

Nebivolol HCl selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM.

YN321699 Mebeverine metabolite O-desm... 155172-67-1

Mebeverine metabolite O-desmethyl Mebeverine alcohol is a metabolite of Mebeverine, which is a potentα1 repectorinhibitor, causing relaxation of the gastrointestinal tract.

YN321215 L755507 159182-43-1

L-755,507 is characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 of 0.43 nM. It is also recently identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human in...