YN251858 Human β-defensin-1 452274-53-2

Human β-defensin-1 (HβD-1) is a cysteine-rich cationicskin-antimicrobial peptide (SAP)produced by all epithelial surfaces, but also by circulatory cells and cells of the reproductive tract. Human β-defensin-1 has antimicrobial...

YN250617 SQ109 502487-67-4

SQ109 is a potent inhibitor of thetrypomastigoteform of the parasite, with IC50for cell killing of 50±8nM. SQ109, targetsMmpL3, is an antitubercular agent.

YN250668 Deferasirox (Fe3+ chelate) 554435-83-5

Deferasirox Fe3+ chelate is a rationally-designed oral iron chelator; its main use is to reduce chronic iron overload in patients who are receiving long-term blood transfusions for conditions such as beta-thalassemia and other chronic ...

YN250686 AFN-1252 620175-39-5

AFN-1252(Debio 1452) is a potent inhibitor of enoyl-acyl carrier protein reductase (FabI), inhibited all clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis at concentrations of ≤0.12 μg/ml.

YN250640 CHIR-090 728865-23-4

CHIR-090 is a potent, slow, tight-binding inhibitor of theLpxCdeacetylase. It binds toE. coliLpxCwith a Ki of 4.0nM.

YN251694 Tropodithietic acid 750590-18-2

Tropodithietic acid is a sulfur-containing antibiotic produced by the marine bacteriumPhaeobacter inhibens. Tropodithietic acid exhibits a strong antibiotic activity against a broad spectrum of bacteria including alpha- and gammaproteo...

YN250765 Solithromycin 760981-83-7

Solithromycin, belonging to the well-known class of macrolide antibiotics that also includes azithromycin, is a potent bacterial protein synthesis inhibitor.

YN250353 ML406 774589-47-8

ML406 is a small molecule probe that showsanti-tubercularactivity viaM.tuberculosisBioA(DAPA synthase) enzyme inhibition with an IC50 of 30nM.M.tuberculosisBioA is an enzyme involved in biotin biosynthesis inM.tuberculosis.

YN250205 MCB-3681 790704-42-6

MCB-3681 is the antibacterial Oxaquin's active substance, active against gram-positive bacterium.

YN251822 PBP10 794466-43-6

PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor offormyl peptide receptor 2 (FPR2)over FPR1. PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity agai...

YN251817 LF11 832729-13-2

LF11 is a peptide withantibacterialactivity.

YN251816 Lauryl-LF 11 832729-14-3

Lauryl-LF 11, N-terminally acylated analogue of LF11, is a peptide withantibacterialactivity.

YN250442 MAC-545496 838810-96-1

MAC-545496 is a nanomolar glycopeptide-resistance-associated protein R(GraR) inhibitor with strong binding affinity to the full-length GraR protein (Kd ≤ 0.1 nM). MAC-545496 can reverse β-lactam resistance in methic...

YN250610 Bedaquiline 843663-66-1

Bedaquiline(TMC207; R207910) is an anti-tuberculosis drug which selectively inhibit the mycobacterial energy metabolism i.e. ATP synthesis and found to be effective against all states of Mycobacterium tuberculosis.

YN250611 Bedaquiline fumarate 845533-86-0

Bedaquiline fumarate, an oral diarylquinoline, is a bactericidal antimycobacterial drug. It is a proton-translocating ATP synthetase inhibitor.

YN250420 dmDNA31 845625-44-7

dmDNA31 is a rifamycin-class antibiotic that inhibits bacterial DNA-dependent RNA polymerase with potent bactericidal activity against S.aureus.

YN250604 Tedizolid 856866-72-3

Tedizolid phosphate is a novel oxazolidinone with activity against Gram-positive pathogens.

YN250605 Tedizolid phosphate 856867-55-5

Tedizolid is an oxazolidinone-class antibiotic. Tedizolid phosphate is a phosphate ester prodrug of the active compound tedizolid.

YN250176 Salicyl-AMS 863238-55-5

Salicyl-AMS is amycobactin biosynthesisinhibitor which can also inhibitM. tuberculosisgrowthin vitrounder iron-limited conditions.

YN250074 KKL-35 865285-29-6

KKL-35 inhibits the trans-translation tagging reaction with an IC50 of 0.9 µM. It has broad-spectrum antibiotic activity.