YN483453 Angelicain 49624-66-0

Angelicain (Norcimifugin) is a constituent ofCimicifuga foetidawith anti-inflammatory activity.

YN310266 Selisistat 49843-98-3

Selisistat (EX 527) is a potent and selective SIRT1 inhibitor with IC50 of 38 nM in a cell-free assay, exhibits >200-fold selectivity against SIRT2 and SIRT3. Phase 2.

YN270503 Cucurbitacin IIb 50298-90-3

Cucurbitacin IIb (CuIIb, Dihydrocucurbitacin F, 25-deacetyl hemslecin A) inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB, blocks nuclear translocation of NF-κB and...

YN321624 Terfenadine 50679-08-8

Terfenadine is an antihistamine, generally completely metabolizes to the active form fexofenadine in the liver by the enzyme cytochrome P450 CYP3A4 isoform.

YN372852 Ibudilast 50847-11-5

Ibudilast is a relatively non-selective phosphodiesterase inhibitor with anti-inflammatory and neuroprotective activities.

YN290411 Pirinixic acid 50892-23-4

WY 14643 (Pirinixic Acid) is a potent peroxisome proliferator and activator of PPARα with EC50 of 1.5 μM.

YN250732 Mizoribine 50924-49-7

Mizoribine is an imidazole nucleoside, selectively inhibits inosine monophosphate synthetase and guanosine monophosphate synthetase.

YN310350 Verminoside 50932-19-9

Verminoside is an iridoid isolated fromKigelia africana, exhibits anti-inflammatory and remarkable antioxidant activity with a radical-scavenging activity of 2.5 μg/mL. The genotoxicity of Verminoside on human lymphocytes is associa...

YN290528 Ankaflavin 50980-32-0

Ankaflavin, isolated from Monascus-Fermented red rice, is aPPARγagonist with anti-inlfammatory activity. Ankaflavin exhibits selective cytotoxic effect and induces cell death on cancer cells.

YN482614 6''-O-Malonylgenistin 51011-05-3

6''-O-Malonylgenistin(Malonylgenistin) is an isoflavone derivative.

YN321747 Licarin A 51020-86-1

Licarin A ((+)-Licarin A), a neolignan isolated from various plants, significantly and dose-dependently reduces TNF-α production (IC50=12.6±0.3μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 ce...

YN321625 Amcinonide 51022-69-6

Amcinonide (Cyclocort, CL-34699) is an inhibitor of nitric oxide (NO) release from activated microglia with IC50 of 3.38 nM.

YN321497 Salbutamol hemisulfate 51022-70-9

Salbutamol Sulfate is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 ?M.

YN280128 Wogonoside 51059-44-0

Wogonoside, a flavonoid glycoside isolated from Huangqin, possesses anti-inflammatory effects. Wogonoside induces autophagy in breast cancer cells by regulating MAPK-mTOR pathway.

YN330201 2-Hydroxy Ibuprofen 51146-55-5

2-Hydroxy Ibuprofen is a metabolite of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13μM and 370μM, respectively.

YN330395 (S)-(+)-Ibuprofen 51146-56-6

(S)-(+)-Ibuprofen ((S)-Ibuprofen), a S(+)-enantiomer of Ibuprofen, is a potentCOX-1 and COX-2 inhibitor with IC50s of 2.1μM and 1.6μM, respectively. (S)-(+)-Ibuprofen has analgesic, anti-inflammatory, anticancer and ...

YN410083 (R)-(-)-Ibuprofen 51146-57-7

(R)-(-)-Ibuprofen ((R)-Ibuprofen) inhibits the activation of NF-κB in response to T-cell stimulation with IC50 of 121.8 μM. R(-)-ibuprofen exerts anti-inflammatory and antinociceptive effects.

YN320760 Budesonide 51333-22-3

Budesonide is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis.

YN330304 (S)-Flurbiprofen 51543-39-6

(S)-Flurbiprofen is an active enantiomer of Flurbiprofen, with IC50 values of 0.48μM and 0.47μM forCOX-1 and COX-2, respectively.

YN370253 Tarenflurbil 51543-40-9

Tarenflurbil ((R)-Flurbiprofen) is the R-enantiomer of the racemate NSAID Flurbiprofen, Tarenflurbil ((R)-Flurbiprofen) inhibits the binding of [3H]9-cis-RA toRXRαLBD with IC50 of 75μM.