YN430219 (S,R,S)-AHPC-C6-NH2 ... 2360522-76-3

(S,R,S)-AHPC-C6-NH2 hydrochloride (VH032-C6-NH2 hydrochloride) is a synthesizedE3 ligase lig and -linker conjugatethat incorporates the VH032 based VHL lig and and a linker used forAKTPROTAC degrader. (S,R...

YN290285 RBN012759 2360851-29-0

RBN012759 is a potent and selective inhibitor of PARP14 with IC50 of <3 nM and 5 nM for human catalytic domain and mouse catalytic domain, respectively. RBN012759 contributes to anti-tumor immune response.

YN270060 GSK840 2361146-30-5

GSK840 (GSK'840) is areceptor-interacting protein kinase 3 (RIP3 or RIPK3)inhibitor, which binds RIP3 kinase domain with an IC50 of 0.9nM, and inhibits kinase activity with an IC50 of 0.3nM.

YN410017 GSK8612 2361659-62-1

GSK8612 is a highly potent and selective inhibitor for TBK1 (Tank-binding Kinase-1) with pKd of 8.0. Within 10-fold affinity with respect to TBK1, no off-targets of GSK8612 could be identified.

YN310189 M‑89 2363165-42-6

M-89 is a highly potent and specificmenininhibitor, with aKdof 1.4nM for binding to menin. M-89 inhibits themenin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia.

YN330140 STING ligand-1 2365039-41-2

STING lig and -1 is a leadSTINGlig and with an IC50 of 68nM for HAQ STING.

YN330214 Complement C5-IN-1 2365402-67-9

Complement C5-IN-1 (Compound 7) is a small-molecule inhibitor of complement component 5 protein (C5). Complement C5-IN-1 interacts with C5 to prevent its cleavage by the C5 convertase and blocks zymosan-induced the membrane-at...

YN330219 G150 2369751-30-2

G150 is a potent and highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor with IC50 of 10.2 nM.

YN330241 SR-717 free acid 2375420-34-9

SR-717 free acid is a non-nucleotideSTINGagonist with EC50s of 2.1μM and 2.2μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 free acid is a stable cyclic guanosin...

YN330240 SR-717 2375421-09-1

SR-717 is a non-nucleotideSTINGagonist with EC50s of 2.1μM and 2.2μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 is a stable cyclic guanosine monophosphate-aden...

YN330106 Ac-FLTD-CMK 2376255-48-8

Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specificinflammatory caspasesinhibitor. Ac-FLTD-CMK is effective againstcaspases-1(IC50 of 46.7nM),caspases-4(IC50 of 1.49μM),caspases-5(IC50 of 329nM...

YN371048 NPD-1335 2376326-31-5

NPD1335 is aTrypanosoma brucei phosphodiesterase B1(TbrPDEB1) inhibitor with submicromolar activities againstT. bruceiparasites. NPD1335 displays a greatly improved cytotoxicity profile. NPD1335 increases intracellular cAM...

YN250389 ZL0580 2377151-10-3

ZL0580, a structurally close analog of ZL0590, induces epigenetic suppression ofHIVvia selectively binding to BD1 domain ofBRD4. ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongati...

YN330138 PF-06928215 2378173-15-8

PF-06928215 is acGAS (cyclic GMP-AMP Synthase)inhibitor with an IC50 of 4.9 μΜ. PF-06928215 has a high binding affinity of 0.2μM (Kd).

YN440242 Src Inhibitor 3 2380027-49-4

Src Inhibitor 3 is a potent, orally activec-terminal Src kinase (CSK)with IC50 values below 3nM and 4nM in CSK HTRF and Caliper assay, respectively. Src Inhibitor 3 shows the ability to increase T cell proliferation...

YN480998 NF-56-EJ40 2380230-73-7

NF-56-EJ40 is a potent, high-affinity, and highly selectivehuman SUCNR1 (GPR91)antagonist with an IC50 of 25nM and a Ki of 33nM, and shows almost no activity towards ratSUCNR1. NF-56-EJ40 has high affinity fo...

YN330271 OP-5244 2381268-71-7

OP-5244 is a potent and orally bioavailable inhibitor ofCD73, with an IC50 of 0.25nM. OP-5244 reverses immunosuppression through blocking of adenosine production, and has the potential for the cancer research.

YN270214 Bcl-2-IN-2 2383085-86-5

Bcl-2-IN-2 is a potent and selectiveBcl-2inhibitor with an IC50 of 0.034nM and also inhibits Bcl-xL with an IC50 of 43nM, showing >1000-fold selectivity for Bcl-2 over Bcl-xL.

YN370484 cGAMP disodium 2407516-83-8

cGAMP disodium (Cyclic GMP-AMP disodium) is the third cyclic dinucleotide (CDN) to be discovered in bacteria. cGAMP disodium is an effective adjuvant for sublingual vaccination capable of promoting broad immunity including...

YN480477 LDC7559 2407782-01-6

LDC7559 is agasdermin D (GSDMD)inhibitor via blocking neutrophil extracellular trap (NET) in the late stages.