YN350138 SR-318 2413286-32-3

SR-318 is a potent and highly selectivep38 MAPKinhibitor with IC50s of 5nM, 32nM and 6.11μM for p38α, p38β and p38α/β, respectively. SR-318 potently inhibits theTNF-αrelease in whole blood with an IC50 of 283nM...

YN360441 P2X3 antagonist 34 2417288-67-4

P2X3 antagonist 34 is a potent, selective and orally activeP2X3 homotrimeric receptorantagonist with IC50s of 25 nM, 92 nM and 126 nM forhuman P2X3,rat P2X3 and guinea pig P2X3 receptors, respectively. P2X3 antagonis...

YN320477 CCR1 antagonist 6 2436773-01-0

CCR1 antagonist 6 (compound 16q) is achemokine receptor 1 (CCR1)antagonist, with an IC50 of 3nM.

YN330373 T6167923 2437475-16-4

T6167923 is a potent and selective inhibitor ofMyD88-dependent signalingpathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-κB dr...

YN320458 CCR6 inhibitor 1 2437547-04-9

CCR6 inhibitor 1 is a potent and selectiveCCR6inhibitor, with IC50s of 0.45 and 6nM for monkey and human CCR6, much more selective at CCR6 over human CCR1 (IC50, > 30000nM), and CCR7 (IC50, 9400nM). CCR...

YN320478 CCR1 antagonist 7 2446154-74-9

CCR1 antagonist 7 (compound 16r) is achemokine receptor 1 (CCR1)antagonist, with an IC50 of 4nM.

YN280043 BRD5631 2446154-91-0

BRD5631 is anautophagyenhancer, enhancesautophagythrough an mTOR-independent pathway. BRD5631 affects several cellular disease phenotypes previously linked to autophagy, including protein aggregation, cell survival, bacterial repli...

YN330233 YQ128 2454246-18-3

YQ128 is a potent and selective second-generationNLRP3 (NOD-like receptor P3) inflammasomeinhibitor with an IC50 of 0.30 µM. YQ128 significantly and selectively suppresses the production ofIL-1β, but not TNF-α, a...

YN330266 BMS-986251 2460133-35-9

BMS-986251 is an orally active and selectiveRORγtinverse agonist with an EC50 of 12nM for RORγt GAL4. BMS-986251 inhibitsIL-17with an EC50 of 24nM in human whole blood assay. BMS-986251 demonstrates robust effi...

YN310235 GSK046 2474876-09-8

GSK046 (iBET-BD2) is a selective and orally active inhibitor of BET (bromodomain and extraterminal domain) with IC50 of 264 nM, 98 nM, 49 nM and 214 nM for BRD2_BD2, BRD3_BD2, BRD4