YN340055 Fedratinib hydrochloride hydr... 1374744-69-0

Fedratinib hydrochloride hydrate (TG-101348 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally activeJAK2inhibitor with IC50s of 3nM for bothJAK2 and JAK2V617F kinase. Fedratinib hydrochloride h...

YN340020 PF-06263276 1421502-62-6

PF-06263276 (PF 6263276) is a potent and selectivepan-JAKinhibitor, with IC50s of 2.2nM, 23.1nM, 59.9nM and 29.7nM for JAK1, JAK2, JAK3 and TYK2, respectively.

YN340037 Gusacitinib 1425381-60-7

Gusacitinib (ASN-002) is an orally active and potent dual inhibitor of spleen tyrosine kinase (SYK) and janus kinase (JAK) with IC50 values of 5-46nM. Gusacitinib has anti-cancer activity in both solid and hematological ...

YN340031 JAK3-IN-6 1443235-95-7

Selective JAK3 inhibitor 1 is an irreversible JAK3 inhibitor with Ki values of 0.07 nM, 320 nM, 740 nM for JAK3, JAK1 and JAK2 respectively. It is also selective over the other kinases possessing a cysteine in th...

YN340080 SHR0302 1445987-21-2

SHR0302 is a potent and orally active all members of theJAK familyinhibitor, particularlyJAK1. The selectivity of SHR0302 forJAK1is >10-fold forJAK2, 77-fold forJAK3, 420-fold forTyk2. SHR0302 inhibitsJAK1-ST...

YN340017 SAR-20347 1450881-55-6

SAR-20347 is an inhibitor of TYK2,JAK1,JAK2 and JAK3 with IC50s of 0.6, 23, 26 and 41nM, respectively.

YN340064 Abrocitinib 1622902-68-4

PF-04965842 is a potent JAK1 inhibitor with IC50s of 29 nM, 803 nM, > 10 000 nM and 1250 nM for JAK1, JAK2, JAK3 and tyrosine kinase (TYK) 2, respectively.

YN340138 Oclacitinib maleate 1640292-55-2

Oclacitinib(PF 03394197) is a novel inhibitor of JAK family members with IC50 ranging from 10 to 99 nM and JAK1-dependent cytokines with IC50 ranging from 36 to 249 nM. It does not inhibit a panel of 38 non-JAK kinases.

YN340015 PF-06651600 1792180-81-4

PF-06651600 is a potent and irreversible JAK3-selective inhibitor with an IC50 of 33.1 nM but without activity (IC50 > 10 000 nM) against JAK1, JAK2, and TYK2.

YN340074 Tyk2-IN-5 1797432-62-2

Tyk2-IN-5 (compound 6) is a highly potent, selective and orally activeTyk2inhibitor and targets the JH2 domain, with a Ki of 0.086nM for Tyk2 JH2 and an IC50 of 25nM for IFNα. Highly effective in inhibiting IFNγ...

YN340217 JAK3-IN-1 1805787-93-2

JAK3-IN-1 is a potent, selective and orally activeJAK3inhibitor with an IC50 of 4.8nM. JAK3-IN-1 shows over 180-fold more selective forJAK3than JAK1 (IC50 of 896nM) and JAK2 (IC50 of 1050nM).

YN340214 CHZ868 1895895-38-1

CHZ868 is a type IIJAK2inhibitor with an IC50 of 0.17μM in EPOR JAK2 WT Ba/F3 cell.

YN340160 NVP-BSK805 dihydrochlori... 1942919-79-0

NVP-BSK805 dihydrochloride is an ATP-competitiveJAK2inhibitor, with IC50s of 0.48nM, 31.63nM, 18.68nM, and 10.76nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively.

YN340060 AZD4205 2091134-68-6

AZD4205 is a selectiveJAK1inhibitor, with an IC50 of 73nM, weakly inhibits JAK2 (IC50>14.7μM), and shows little inhibition on JAK3 (IC50>30μM).

YN340026 TyK2-IN-2 2098466-94-3

TyK2-IN-2 (Compoud 18) is a potent and selectiveTYK2inhibitor with IC50s of 7nM, 0.1μM and 0.05μM forTYK2 JH2,IL-23 and IFNα, respectively. TyK2-IN-2 also inhibitsphosphodiesterase 4 (PDE4)with an IC50...

YN340107 PF-06826647 2127109-84-4

PF-06826647 is an orally active and selectiveTYK2inhibitor (IC50=17nM), which binds to TYK2 catalytically active JH1 domain. PF-06826647 displays selectivity for TYK2 over JAK1 (IC50=383nM) and JAK2 (74nM). P...

YN340108 Tyk2-IN-9 2127109-85-5

Tyk2-IN-9 is a potent,selective and specific inhibitor ofJAK kinases, inhibits Tyk2, JAK1 and JAK2 with IC50 values of 6nM, 21nM and 6nM, respectively. Tyk2-IN-9, example 19, is extracted from patent US20172405...

YN340079 PF-06700841 P-Tosylate 2140301-96-6

PF-06700841 P-Tosylate is a potent dualJanus kinase 1 (JAK1) and TYK2inhibitor with IC50s of 17nM and 23nM, respectively. PF-06700841 P-Tosylate also inhibitsJAK2 and JAK3with IC50s of 77nM and 6.49μM, resp...

YN340124 FM-479 2226521-64-6

FM-479 is thenegative controlof FM-381 (HY-102046) and has no activity on JAK3 or other kinases. FM-381 is a potent covalent reversible inhibitor ofJAK3targeting the unique Cys909. FM-381 has an IC50 of 127 pM for JA...

YN340032 FM-381 2226521-65-7

FM-381 is a potent covalent reversible inhibitor ofJAK3targeting the unique Cys909. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.