Brevilin A
Cat. No. :YN340278
CAS No. :16503-32-5
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order@ubiochem.com| Product Name: | Brevilin A |
| CAS NO.: | 16503-32-5 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 346.42 |
| Molecular Formula: | C₂₀H₂₆O₅ |
| SMILES: | C/C=C(C)C(O[C@H]1[C@@]([C@@H]2C)([H])[C@@](OC2=O)([H])C[C@@H](C)[C@@]3([H])[C@]1(C(C=C3)=O)C)=O |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Brevilin A is a sesquiterpene lactone isolated fromCentipeda minimawith anti-tumor activity. Brevilin A is a selective inhibitor ofJAK-STATsignal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50= 10.6 µM) in Cancer Cells. Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26. |
| IC50&Target: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: | |
| References: |
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