Fedratinib hydrochloride hydrate
Cat. No. :YN340055
CAS No. :1374744-69-0
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order@ubiochem.com| Product Name: | Fedratinib hydrochloride hydrate |
| CAS NO.: | 1374744-69-0 |
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| Molecular Weight: | 615.62 |
| Molecular Formula: | C₂₇H₄₀Cl₂N₆O₄S |
| SMILES: | [H]Cl.[H]O[H].[H]Cl.O=S(C1=CC=CC(NC2=NC(NC3=CC=C(C=C3)OCCN4CCCC4)=NC=C2C)=C1)(NC(C)(C)C)=O |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Fedratinib hydrochloride hydrate (TG-101348 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally activeJAK2inhibitor with IC50s of 3nM for bothJAK2 and JAK2V617F kinase. Fedratinib hydrochloride hydrate shows 35- and 334-fold selectivity over JAK1 and JAK3, respectively. Fedratinib hydrochloride hydrate induces cancer cellapoptosis and has the potential for myeloproliferative disorders research. |
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