Tyk2-IN-5
Cat. No. :YN340074
CAS No. :1797432-62-2
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order@ubiochem.com| Product Name: | Tyk2-IN-5 |
| CAS NO.: | 1797432-62-2 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 434.43 |
| Molecular Formula: | C₂₁H₁₉FN₈O₂ |
| SMILES: | O=C1C(NC2=NN3C(C(NC)=C2)=NC=C3C(N[C@H]4[C@@H](F)C4)=O)=CC=CN1C5=CC=CC=N5 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Tyk2-IN-5 (compound 6) is a highly potent, selective and orally activeTyk2inhibitor and targets the JH2 domain, with a Ki of 0.086nM for Tyk2 JH2 and an IC50 of 25nM for IFNα. Highly effective in inhibiting IFNγ production in a rat pharmacodynamics model and fully efficacious in a rat adjuvant arthritis model. |
| IC50&Target: | |
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