YN321135 Guanfacine 29110-47-2

Guanfacine is a selective α2A receptor agonist. Guanfacine is a sympatholytic. It is a selective α2A receptor agonist. These receptors are concentrated heavily in the prefrontal cortex and the locus coeruleus, with the potential t...

YN321149 Atenolol 29122-68-7

Atenolol is a selective β1 receptor antagonist with log Kd values of ?6.66±0.05, ?5.99±0.14, ?4.11±0.07 for binding to the human β1-, β2- and β3-adrenoceptors.

YN380090 Toloxatone 29218-27-7

Toloxatone (MD 69276) is a reversible inhibitor of monoamine oxidase A (MAO-A) with IC50 of  0.93 µM. Toloxatone is an antidepressant agent.

YN270491 Thevetiaflavone 29376-68-9

Thevetiaflavone could upregulate the expression ofBcl‑2 and downregulate that ofBax and caspase‑3.

YN482669 Tabersonine hydrochloride 29479-00-3

Tabersonine, an ingredient extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1?42) aggregation and toxicity.

YN330637 Negletein 29550-13-8

Negletein is a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Negletein shows promising anti-inflammatory activity via inhibition ofTNF-α and IL-1βwith IC50 values of 1...

YN360179 Almitrine mesylate 29608-49-9

Almitrine mesylate (Almitrine bismesylate, Almitrine dimethanesulfonate, Almitrine dimesylate), a pharmacologically unique respiratory stimulant, acts as an agonist of peripheral chemoreceptors located on the carotid bodies. Alm...

YN360192 Dihydro-β-erythroidine hydro... 29734-68-7

Dihydro-β-erythroidine (DHβE) hydrobromide is a potent, orally active, and competitive antagonist of neuronalnAChRs. Dihydro-β-erythroidine hydrobromide shows selectivity for α4β4 and α4β2 nAChRs, with IC50s of 0.19 ...

YN370985 N-Desmethyl Clomipramine hy... 29854-14-6

N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine. Clomipramine is a tricyclic antidepressant.

YN321107 Pirenzepine dihydrochloride 29868-97-1

Pirenzepine is an antimuscarinic agent which inhibits gastric acid secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular and urinary functions.

YN372833 S-Adenosyl-L-methionine 29908-03-0

Ademetionine, also known as SAMe, is a specific form of the amino acid methionine known as S-adenosyl-methionine. It is essential for the formation of glutathione, a water-soluble peptide that helps the body fight free radicals.

YN360997 6-Methylflavone 29976-75-8

6-Methylflavone is an activator of α1β2γ2L and α1β2GABAAreceptors.

YN321316 Tianeptine sodium salt 30123-17-2

Tianeptine sodium is a selective serotonin reuptake enhancer (SSRE), used for treating major depressive episodes.

YN360974 24-Hydroxycholesterol 30271-38-6

24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator ofN-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factorsLXR.

YN484200 Suclofenide 30279-49-3

Suclofenide (Neosulfalepsine;PB385) is an anticonvulsant agent.

YN321755 Corydalmine 30413-84-4

Corydalmine (L-Corydalmine), an alkaloid isolated from roots ofCorydalis Chaerophylla, inhibits spore germination of some plant pathogenic as well as saprophytic fungi. Corydalmine acts as an oral analgesic agent, exhibiting potent an...

YN360775 Flunarizine dihydrochloride 30484-77-6

Flunarizine 2HCl is a dihydrochloride salt form which is a calcium channel blocker with a Ki of 68 nM.

YN290437 TCID 30675-13-9

TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1.

YN320717 Flumexadol 30914-89-7

Flumexadol is an orally active non-narcotic analgesic. Flumexadol is a selective and affinity5-HT2Creceptoragonist with a Ki of 25nM for the (+)-enantiomer of Flumexadol, and is 40-fold selective over the 5-HT2Areceptor.

YN321603 Lofexidine 31036-80-3

Lofexidine is a selectiveα2-receptoragonist, commonly used to alleviate the physical symptoms of heroin and other types of opioid withdrawal.