YN320485 VU6012962 2313526-86-0

VU6012962 is an orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 negative allosteric modulator (mGlu7NAM) with an IC50 of 347nM.

YN360141 SSD114 hydrochloride 2319790-02-6

SSD114 hydrochloride is a novelGABABreceptorpositive allosteric modulator.

YN480387 Ceapin-A7 2323027-38-7

Ceapin-A7 is a selective blocker ofATF6α signalingin response to ER stress, with an IC50 of 0.59μM. Ceapin-A7 can be used to explore both the mechanism of activation of ATF6α and its role in pathological settings.

YN360366 Nav1.1 activator 1 2332897-85-3

Nav1.1 activator 1 (compound 4), a highly potentNav1.1activator withBBB penetration, increases decay time constant (tau) of Nav1.1 currents at 0.03μM along with significant selectivity against Nav1.2, Nav1.5, and Nav1.6.

YN450069 NCC007 2342583-66-6

NCC007 is a dualcasein kinase Iα (CKIα) and δ (CKIδ)inhibitor with IC50s of 1.8 and 3.6μM, respectively. NCC007 can be used in research of modulating mammalian circadian rhythms.

YN410017 GSK8612 2361659-62-1

GSK8612 is a highly potent and selective inhibitor for TBK1 (Tank-binding Kinase-1) with pKd of 8.0. Within 10-fold affinity with respect to TBK1, no off-targets of GSK8612 could be identified.

YN371116 MR-L2 2374703-19-0

MR-L2 is a reversible and noncompetitive allosteric activator of long-isoformphosphodiesterase-4 (PDE4), activates representative PDE4 long-isoform variants (PDE4A4, PDE4B1, PDE4C3, PDE4D5). MR-L2 suppresses P...

YN371342 LEI-401 2393840-15-6

LEI-401 is a first-in-class, selective, and CNS-activeNAPE-PLD(N-acylphosphatidylethanolamine phospholipase D) inhibitor, with an IC50 of 27nM. LEI-401 modulates emotional behavior in mice.

YN360443 SUVN-911 2414674-71-6

SUVN-911 is a potent, selective, brain penetrated and orally bioavailable neuronal nicotinic acetylcholineα4β2 receptorantagonist, with a Ki of 1.5nM. SUVN-911 has antidepressant activity.

YN310160 Nicotinamide riboside tartrat... 2415657-86-0

Nicotinamide riboside tartrate, an orally active NAD+precursor, increases NAD+levels and activatesSIRT1 and SIRT3. Nicotinamide riboside tartrate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, pro...

YN310161 Nicotinamide riboside malate 2415659-01-5

Nicotinamide riboside malate, an orally active NAD+precursor, increases NAD+levels and activatesSIRT1 and SIRT3. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protect...

YN410050 CBR-470-1 2416095-06-0

CBR-470-1 is an inhibitor of theglycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalentNrf2activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP+-induced cytotoxicity through acti...

YN360441 P2X3 antagonist 34 2417288-67-4

P2X3 antagonist 34 is a potent, selective and orally activeP2X3 homotrimeric receptorantagonist with IC50s of 25 nM, 92 nM and 126 nM forhuman P2X3,rat P2X3 and guinea pig P2X3 receptors, respectively. P2X3 antagonis...

YN380071 Aβ42-IN-1 free base 2434633-17-5

Aβ42-IN-1 free base (compound 1v) is an orally active, high brain exposureγ-secretasemodulator. Aβ42-IN-1 free base potently reduces Aβ42 levels with an IC50 value of 0.091 µM, and significantly reduces brain Aβ42 levels ...

YN360262 (Rac)-NMDAR antagonist 1 2435557-99-4

(Rac)-NMDAR antagonist 1 is the racemate of NMDAR antagonist 1.nMDAR antagonist 1 is a potent and orally bioavailable NR2B-selectiveNMDARantagonist.

YN280041 (Rac)-BL-918 2435589-07-2

(Rac)-BL-918 is the racemate of BL-918. BL-918 is a potent activator ofUNC-51-like kinase 1 (ULK1), inducing cytoprotective autophagy for Parkinson’s disease treatment.

YN360289 DS16570511 2446154-84-1

DS16570511 is cell-permeable inhibitor of themitochondrial calcium uniporter, which blocks the MCU- or MICU1-dependent increase of Ca2+influx.

YN360444 TC-2559 difumarate 2454492-41-0

TC-2559 idifumarate is a CNS-selective, orally activeα4β2subtype of nicotinic acetylcholine receptor (nAChR) partial agonist (EC50=0.18μM). TC-2559 difumarate shows selectivity for α4β2 over α2β4, α4β4 and α3β4 rec...

YN-D1528 MTSEA-Fluorescein 1356019-48-1

MTSEA-Fluorescein 是一种可用于离子通道研究的荧光探针。