YN320348 VU6005649 2137047-43-7

VU6005649 is a CNS penetrantmGlu7/8receptoragonist with EC50s of 0.65μM and 2.6μM formGlu7receptor and mGlu8receptor, respectively.

YN320980 Vortioxetine D8 2140316-62-5

Vortioxetine D8 is a deuterium labeled Vortioxetine. Vortioxetine is an inhibitor of5-HT1A, 5-HT1B, 5-HT3A, 5-HT7receptor and SERT, with Ki values of 15nM, 33nM, 3.7nM, 19nM and 1.6nM, respectively .

YN480810 PZ-2891 2170608-82-7

PZ-2891 is a selective, orally active and brain-penetrant pantothenate kinase (PANK) modulator that acts as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ...

YN320521 LY2794193 2173037-97-1

LY2794193 is a highly potent and selectivemGlu3 receptoragonist (hmGlu3Ki=0.927nM，EC50=0.47nM;hmGlu2Ki=412nM，EC50=47.5nM).

YN420129 Rheb inhibitor NR1 2216763-38-9

Rheb inhibitor NR1 is aRhebinhibitor with an IC50 of 2.1 µM in the Rheb-IVK assay. Rheb inhibitor NR1 also is a selectivemTORC1inhibitor. NR1 inhibits the phosphorylation ofT389pS6K1 and increases the phosphorylat...

YN480676 KSC-34 2226201-97-2

KSC-34 is a potent and site-selective inhibitor ofPDIA1(containing two active-site domains a and a′). KSC-34 displays a 30-fold selectivity for a domain over a′ domain and time-dependent inhibition of PDIA1 reductase a...

YN360156 Loreclezole hydrochloride 2227372-56-5

Loreclezole hydrochloride, an antiepileptic compound, is a selectiveGABAAreceptormodulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors.

YN370988 Raphin1 acetate 2242616-04-0

Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 acetate binds strongly to the R15B-PP1c holophosphatase with Kd of 0.033 μM.

YN360286 (-)-(S)-B-973B 2244989-34-0

(-)-(S)-B-973B is a potent allosteric agonist and positive allosteric modulator ofα7 nAChR, with antinociceptive activity.

YN320598 LIT-001 2245072-21-1

LIT-001 is the first nonpeptideoxytocin receptor (OT-R)agonist (EC50=55nM;Ki=226nM). LIT-001 improves social interaction in a mouse model of autism.

YN321124 Clozapine N-oxide dihydrochl... 2250025-93-3

Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and ahuman muscarinic designer receptors (DREADDs)agonist. Clozapine N-oxide dihydrochloride activates theDREADD receptor hM3Dq and hM4Di. Clozapin...

YN360445 nAChR agonist CMPI hydr... 2250025-94-4

nAChR agonist CMPI hydrochloride is a potent and selective positive allosteric modulator (PAM) ofnAChRcontaining a α4:α4 subunit interface. nAChR agonist CMPI hydrochloride enhances the response of(α4)3(β2)2nAChR...

YN370584 SHIP2-IN-1 2252247-80-4

SHIP2-IN-1 is a potentSHIP2inhibitor, inhibits SHIP2 activity, with an IC50 of 2 µM. SHIP2-IN-1 blocks GSK3β activation by phosphorylation at the Ser9 residue. SHIP2-IN-1 is used in the research of Alzhei...

YN481277 DMNPE-4 AM-caged-calciu... 2253744-58-8

DMNPE-4 AM-caged-calcium, photolabile analogues of EGTA, is an extremely effective Ca2+selective cage, with aKdfor Ca2+of 48nM and 19nM at pH 7.2 and pH 7.4, respectively. DMNPE-4 AM-caged-calcium has a lower af...

YN270120 UAMC-3203 hydrochloride 2271358-65-5

UAMC-3203 hydrochloride is a potent and selectiveFerroptosisinhibitor with an IC50 of 12nM.

YN480396 Real Thiol 2280796-90-7

Real Thiol is a reversible reaction-based fluorescent probe which can quantitatively monitor the real-time glutathione dynamics in living cells.

YN480397 RT-AM 2280796-94-1

RT-AM is a pro-drug real thiol. Real Thiol is a reversible reaction-based fluorescent probe which can quantitatively monitor the real-time glutathione dynamics in living cells.

YN483753 (Arg)9 TFA 2283335-13-5

(Arg)9 TFA (Nona-L-arginine TFA), a cell-penetrating peptide, exhibits neuroprotective activity with an IC50 of 0.78μM in the glutamic acid model.

YN370791 DO-264 2301866-59-9

DO-264 is a selective and in vivo-active inhibitor of Abhydrolase Domain Containing 12 (ABHD12), with an IC50 of 11nM.

YN360417 GFB-8438 2304549-73-1

GFB-8438 is a novel, potent, and subtype selective TRP channel subfamily C (TRPC) inhibitor that is equipotent against TRPC4 and TRPC5 with IC50 of 0.18 μM and 0.29 μM, and shows excellent selec...