YN310312 TAS-301 193620-69-8

TAS-301 is an inhibitor of smooth muscle cell migration and proliferation and inhibits intimal thickening after balloon injury to rat carotid arteries.

YN310213 PKCβ inhibitor 1 257879-35-9

PKCβ inhibitor 1 is a potent, ATP-competitive, and selectivePKCβinhibitor with IC50s of 21 and 5nM for human PKCβ1 and PKCβ2, respectively. PKCβ inhibitor 1 exhibits selectivity of more than 60-fold in favor ...

YN310065 Sotrastaurin 425637-18-9

Sotrastaurin is a potent and selective pan-PKC inhibitor, mostly for PKCθ with Ki of 0.22 nM in a cell-free assay inactive to PKCζ. Phase 2.

YN310166 TPPB 497259-23-1

TPPB is a cell-permeable benzolactam-derived protein kinase C (PKC) activator with a Ki of 11.9nM.

YN310133 PKC-theta inhibitor 736048-65-0

PKC-theta inhibitor inhibits PKC-θ with an IC50 of 12 nM.

YN310201 O-Desmethyl Midostaurin 740816-86-8

O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin me...

YN310176 p32 Inhibitor M36 802555-85-7

p32 inhibitor M36 (M36) is ap32mitochondrial protein inhibitor, which binds directly to p32 and inhibits p32 association with LyP-1.

YN310373 ZIP 863987-12-6

ZIP is a selective peptide inhibitor ofPKMζ. ZIP injections can block the impairment in morphine conditioned place preference induced.

YN310059 CMPD101 865608-11-3

CMPD101 is a potent, highly selective and membrane-permeable small-molecule inhibitor ofGRK2/3with IC50 of 18nM and 5.4nM, respectively. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKC...

YN310079 Delcasertib 949100-39-4

Delcasertib (KAI-9803) is a potent and selective δ-protein kinase C (δPKC) inhibitor. Delcasertib (KAI-9803) could ameliorate injury associated with ischemia and reperfusion in animal models of acute myocardial infarction ...

YN310298 PKC-IN-1 1046787-18-1

PKC-IN-1 is a potent, ATP-competitive and reversible inhibitor of conventionalPKCenzymes with Kis of 5.3 and 10.4nM for human PKCβ and PKCα, and IC50s of 2.3, 8.1, 7.6, 25.6, 57.5, 314, 808nM for PKCα, PK...

YN310279 Afuresertib 1047644-62-1

Afuresertib (GSK2110183) is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.

YN310280 Afuresertib hydrochloride 1047645-82-8

Afuresertib hydrochloride (GSK 2110183 hydrochloride) is an orally bioavailable, selective, ATP-competitive and potent pan-Akt kinase inhibitor with Kis of 0.08/2/2.6nM for Akt1/Akt2/Akt3 respectively.

YN310090 TCS 21311 1260181-14-3

TCS 21311 (NIBR3049) is a potent, highly selectiveJAK3inhibitor with an IC50 of 8nM, it displays >100-fold selectivity over JAK1, JAK2 and TYK2. TCS 21311 (NIBR3049) inhibitsPKCα,PKCθ, and GSK3βwi...

YN310134 VTX-27 1321924-70-2

VTX-27 is a selective protein kinase C θ(PKC θ)inhibitor, with Kisof 0.08nM and 16nM for PKC θ and PKC δ.

YN310145 BJE6-106 1564249-38-2

BJE6-106 (B106) is a potent, selective 3rdgenerationPKCδinhibitor with an IC50 of 0.05μM and targets selectivity over classical PKC isozyme PKCα (IC50=50μM). BJE6-106 (B106) induces caspase-dependentapoptosis. ...

YN310095 Ro 32-0432 hydrochloride 1781828-85-0

Ro 32-0432 hydrochloride is a potent, selective, ATP-competitive and orally activePKCinhibitor. TheIC50 values of Ro 32-0432 hydrochloride forPKCα,PKCβI,PKCβII,PKCγ and PKCεare 9.3nM, 28nM, 30nM, 36.5n...

YN310048 LXS196 1874276-76-2

LXS-196 is a selective inhibitor of protein kinase C (PKC).

YN310182 PKC-iota inhibitor 1 2328094-11-5

PKC-iota inhibitor 1 (compound 19) is aprotein kinase C-iota (PKC-ι ℩)inhibitor with an IC50 value of 0.34μM.

YN310343 Daphnetin

Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor, inhibits EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM, respectively, also known to exhibit anti-inflammatory and anti-oxidant activi...