YN310062 Fasudil Hydrochloride 105628-07-7

Fasudil(HA-1077), a potent and selective inhibitor of Rho kinase, displays less potent inhibiton over PKA, PKG, PKC and MLCK with Ki of 1.6, 1.6, 3.3, and 36 μM in cell-free assays, respectively.

YN310377 Protein Kinase C (19-36) 113731-96-7

Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor ofprotein kinase C (PKC), with an IC50 of 0.18μM. Protein Kinase C (19-36) markedly attenuated vascular hyperproliferation and hypertrophy as well as glucose-in...

YN310088 Bisindolylmaleimide IV 119139-23-0

Bisindolylmaleimide IV (Arcyriarubin A) is a potentprotein kinase C (PKC)inhibitor, with IC50s ranging from 0.1 to 0.55μM. Bisindolylmaleimide IV also inhibits PKA (IC50=3.1-11.8μM). Bisindolylmaleimide IV is a pot...

YN310057 Midostaurin 120685-11-2

Midostaurin (PKC412; CGP 41251) is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ,Syk,Flk-1,Akt,PKA,c-Kit,c-Fgr,c-Src,FLT3,PDFRβ and VEGFR1/2with IC50s ranging from 22-500nM.

YN310379 Protein Kinase C (19-31) 121545-65-1

Protein Kinase C (19-31), a peptide inhibitor ofprotein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with a serine at position 25 replacing the wild-type alanine, is used as protein ...

YN310089 UCN-02 121569-61-7

UCN-02 (7-epi-Hydroxystaurosporine) is a selectiveprotein kinase C (PKC)inhibitor produced byStreptomycesstrain N-12, with IC50s of 62nM and 250nM for PKC and protein kinase A (PKA), respectively. UCN-02 (7-epi-H...

YN310250 Ro 31-8220 125314-64-9

Ro 31-8220 is a potentPKCinhibitor, with IC50s of 5, 24, 14, 27, 24 and 23nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b...

YN310371 KT5823 126643-37-6

KT5823, a selective the cGMP-dependent protein kinase (PKG) inhibitor with anKivalue of 0.23μM, it also inhibits PKA and PKC with Ki values of 10μM and 4μM, respectively. KT5823 is a staurosporine-related protei...

YN310363 Decursinol angelate 130848-06-5

Decursinol angelate is a cytotoxic and protein kinase C activating agent from the root of Angelica gigas.

YN310251 Bisindolylmaleimide I 133052-90-1

Bisindolylmaleimide I (GF109203X) is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ in cell-free assays, respectively, showing more than 3000-fold select...

YN310237 Go 6983 133053-19-7

Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ and PKCδ with IC50 of 7 nM, 7 nM, 6 nM and 10 nM, respectively less potent to PKCζ and inactive to PKCμ.

YN310080 SB-218078 135897-06-2

SB-218078 is a potent, selective, ATP-competitive and cell-permeablecheckpoint kinase 1 (Chk1)inhibitor that inhibitsChk1phosphorylation of cdc25C with an IC50 of 15nM. SB-218078 is less potently inhibitsCdc2(IC50 of 250nM...

YN310050 Go6976 136194-77-9

Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3.

YN310249 Ro 31-8220 mesylate 138489-18-6

Bisindolylmaleimide IX (Ro 31-8220 Mesylate) is a pan-PKC inhibitor with IC50 of 5 nM, 24 nM, 14 nM, 27 nM, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively, and also shows potent in...

YN310202 Bisindolylmaleimide VIII ... 138516-31-1

Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) is a potent and selectiveprotein kinase C (PKC)inhibitor with an IC50 of 158nM for rat brain PKC. Bisindolylmaleimide VIII acetate has IC50s of 53, 195, 163, 213...

YN310087 Bisindolylmaleimide X hydroc... 145317-11-9

Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selectiveprotein kinase C (PKC)inhibitor. Bisindolylmaleimide X hydrochloride is a potentcyclin-dependent kinase 2 (CDK2)antagonist with an IC50 of...

YN310105 CGP60474 164658-13-3

CGP60474, a highly potent anti-endotoxemic agent, is a potentcyclin-dependent kinase (CDK)inhibitor (IC50 values are 26, 3, 4, 216, 10, 200 and 13nM for CDK1/B, CDK2/E, CDK2/A, CDK4/D, CDK5/p25, CDK7/H and...

YN310052 Ruboxistaurin hydrochloride 169939-93-9

LY333531 is a β-specific protein kinase C inhibitor. It competitively and reversibly inhibits PKCβ1 and PKCβ2 with IC50 values of 4.7 and 5.9 nM respectively.

YN310064 Enzastaurin 170364-57-5

Enzastaurin (LY317615) is a potent PKCβ selective inhibitor with IC50 of 6 nM in cell-free assays, 6- to 20-fold selectivity against PKCα, PKCγ and PKCε. Phase 3.

YN310374 PKC β pseudosubstrate 172308-76-8

PKC β pseudosubstrate is a selective cell-permeable inhibitor ofPKC.