YN310094 DCPLA-ME 56687-67-3

DCPLA-ME, the methyl ester form of DCPLA, is a potentPKCεactivator for use in the treatment of neurodegenerative diseases.

YN310240 Ingenol 3,20-dibenzoate 59086-90-7

Ingenol 3,20-dibenzoate is a potentprotein kinase C (PKC)isoform-selective agonist. Ingenol 3,20-dibenzoate induces selective translocation of nPKC-delta, -epsilon, and -theta and PKC-mu from the cytosolic fraction to the pa...

YN310259 Staurosporine 62996-74-1

Staurosporine (CGP 41251) is a potent PKC inhibitor for PKCα, PKCγ and PKCη with IC50 of 2 nM, 5 nM and 4 nM, less potent to PKCδ (20 nM), PKCε (73 nM) and little active to PKCζ (1086 nM)...

YN310218 Mitoxantrone 65271-80-9

Mitoxantrone is atopoisomerase IIinhibitor; also inhibits protein kinase C (PKC) activity with an IC50 of 8.5μM.

YN310219 Mitoxantrone dihydrochloride 70476-82-3

Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively.

YN310337 Ingenol Mebutate 75567-37-2

Ingenol Mebutate is an active ingredient inEuphorbia peplus, acts as a potentPKCmodulator, with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively, and has ...

YN310358 Hypocrellin A 77029-83-5

Hypocrellin A, a naturally occurringPKCinhibitor, has many biological and pharmacological properties, such as antitumour, antiviral, antibacterial, and antileishmanial activities. Hypocrellin A is a promising photosensitizer for ...

YN310181 A-3 hydrochloride 78957-85-4

A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of variouskinases. It against PKA (Ki=4.3 µM), casein kinase II (Ki=5.1 µM) and myosin light chain kinase (MLCK) (Ki=...

YN310074 Bryostatin 1 83314-01-6

Bryostatin 1 is a natural macrolide isolated from the bryozoanBugula neritina and is a potent and central nervous system (CNS)-permeablePKCmodulator. Bryostatin 1 binds to the isolated C1 domain ofMunc13-1 and the full-length...

YN310033 HA-100 84468-24-6

HA-100 is an inhibitor of cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinasewith IC50s of 4, 8, 12 and 240μM, respectively.

YN310369 K-252c 85753-43-1

K-252c, a staurosporine analog isolated fromNocardiopsis sp., is a cell-permeablePKCinhibitor, with an IC50 of 2.45 µM. K-252c induces apoptosis in human chronic myelogenous leukemia cancer cells. K-252c also inhibits β-lactamas...

YN310378 Malantide 86555-35-3

Malantide is a synthetic dodecapeptide derived from the site phosphorylated bycAMP-dependent protein kinase (PKA)on the β-subunit of phosphorylase kinase. Malantide is a highly specific substrate forPKAwith aKmof 15μM and s...

YN310163 (-)-Indolactam V 90365-57-4

(-)-Indolactam V is aPKCactivator, with Kis of 3.36nM, 1.03μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and Kds of 5.5nM (η-C1B), 7.7nM (ε-C1B), 8.3nM (δ-C1B), 18.9nM (β-...

YN310085 R 59-022 93076-89-2

R 59-022 (DKGI-I) is adiacylglycerol kinaseinhibitor (IC50=2.8μM). R 59-022 is a5-HTRantagonist, and activatesprotein kinase C (PKC). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and in...

YN310376 [Ala107]MBP(104-118) 99026-77-4

[Ala107]MBP(104-118) is an noncompetitive peptide inhibitors ofprotein kinase C (PKC), with IC50s ranging from 46-145μM.

YN310375 [Ala113]MBP(104-118) 99026-78-5

[Ala113]MBP(104-118) is an noncompetitive peptide inhibitors ofprotein kinase C (PKC), with IC50s ranging from 28-62μM.

YN310367 K-252a 99533-80-9

K-252a, a staurosporine analog isolated fromNocardiopsis sp.soil fungi, inhibitsprotein kinase, with IC50 values of 470nM, 140nM, 270nM, and 1.7nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylas...

YN310368 K-252b 99570-78-2

K-252b, an indolocarbazole isolated from the actinomyceteNocardiopsis, is aPKCinhibitor. K-252b can be used to inhibit extracellular kinases of cells in culture because it can’t pass through cell membrane freely .

YN310063 Fasudil 103745-39-7

Fasudil (HA-1077; AT877), is a nonspecific ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33μM for ROCK 1,IC50s of 0.158μM and 4.58μM, 12.30μM, 1.650μM for ROCK 2 and ...

YN310355 Procyanidin A1 103883-03-0

Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca2+influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects.