AS2863619 free base
Cat. No. :YN340110
CAS No. :2241300-50-3
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order@ubiochem.com| Product Name: | AS2863619 free base |
| CAS NO.: | 2241300-50-3 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 332.32 |
| Molecular Formula: | C₁₆H₁₂N₈O |
| SMILES: | NC1=NON=C1C(N2C3=CC=C4N=C(C)NC4=C3)=NC5=C2C=CN=C5 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | AS2863619 free base enables conversion of antigen-specific effector/memory T cells into Foxp3+regulatory T (Treg) cells for the treatment of various immunological diseases. AS2863619 free base is a potent, orally activecyclin-dependent kinase 8 (CDK8) and CDK19inhibitor with IC50s of 0.61nM and 4.28nM, respectively.STAT5activation enhanced by AS2863619 free base inhibition of CDK8/19, which consequently activates the Foxp3 gene. |
| IC50&Target: | |
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