SI-109
Cat. No. :YN340118
CAS No. :2429877-30-3
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order@ubiochem.com| Product Name: | SI-109 |
| CAS NO.: | 2429877-30-3 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 835.79 |
| Molecular Formula: | C₄₀H₄₄F₂N₇O₉P |
| SMILES: | O=C([C@@H](NC([C@@H]1CC[C@H](CCN(C(C)=O)C[C@@H]2NC(C3=CC(C=C(C(F)(P(O)(O)=O)F)C=C4)=C4N3)=O)N1C2=O)=O)CCC(N)=O)NC(C5=CC=CC=C5)C6=CC=CC=C6 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | SI-109 is a potentSTAT3 SH2 domaininhibitor (Ki=9nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 (IC50=3μM). SI-109 and an analog of CRBN lig and lenalidomide have been used to design PROTAC STAT3 degraderSD-36. |
| IC50&Target: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: | |
| References: |
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