L002
Cat. No. :YN340012
CAS No. :321695-57-2
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order@ubiochem.com| Product Name: | L002 |
| CAS NO.: | 321695-57-2 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 321.35 |
| Molecular Formula: | C₁₅H₁₅NO₅S |
| SMILES: | O=C1C(C)=C/C(C=C1C)=NOS(=O)(C2=CC=C(OC)C=C2)=O |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | L002 is a potent, cell permeable, reversible and specificacetyltransferase p300 (KAT3B)inhibitor with an IC50 of 1.98μM. L002 binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain, blocks histone acetylation and p53 acetylation, and inhibits STAT3 activation. L002 has the potential for hypertension‐induced cardiac hypertrophy and fibrogenesis treatment. |
| IC50&Target: | |
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