Canertinib dihydrochloride
Cat. No. :YN340048
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order@ubiochem.com| Product Name: | Canertinib dihydrochloride |
| CAS NO.: | 289499-45-2 |
| Chemical Name: | |
| Synonyms: | CI-1033 dihydrochloride, PD-183805 dihydrochloride |
| Molecular Weight: | 558.86 |
| Molecular Formula: | C₂₄H₂₇Cl₃FN₅O₃ |
| SMILES: | C=CC(NC1=CC2=C(N=CN=C2C=C1OCCCN3CCOCC3)NC4=CC=C(C(Cl)=C4)F)=O.[H]Cl.[H]Cl |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Canertinib (CI-1033, PD-183805, compound 18) dihydrochloride is a potent and irreversible inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. Canertinib dihydrochloride inhibits cellular EGFR and ErbB2 autophosphorylation with IC50 of 7.4 nM and 9 nM, respectively. |
| IC50&Target: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: | |
| References: |
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